LongevityDB

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polymorphism	factor	odds ratio	pvalue	initial number	replication number	Population	age of cases	shorter lived allele	longer lived allele	study type	reference
APOE e2/e3/e4	APOE	4.40	0.02	179	—	Finn	Minimum age 104	e3, e4	e2	Candidate Region/Gene	11213279
G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination	—	3.19	0.0006	208 vs 514	—	Italian	Mean age 96	non-AAV allele combi	AAV allele combinati	Candidate Region/Gene	21340542
rs1800896	IL10	—	0.031	119 vs 118	—	Jordanian	Mean age 90.2	G	A	Candidate Region/Gene	20518833
G1691A	F5	—	0.004	432 vs 184	—	Polish	Minimum age 95	A	G	Candidate Region/Gene	20720309
rs1799752	ACE	—	0.016	12 vs 190 vs 105	—	Greek	99-111	D	I	Candidate Region/Gene	23389097
-	Insulin signaling pathway (IIS)	—	0.01	403 vs 1670	—	European	90-103	—	—	Genome-Wide Association Study	22113349
-	Telomere maintenance pathway (TM)	—	0.02	403 vs 1670	—	European	90-103	—	—	Genome-Wide Association Study	22113349
ACE D/I	ACE	—	0.02	689	—	Danish	Minimum age 73	II	DI, DD	Candidate Region/Gene	12547486
ADA genotypes	ADA	—	0.003	62 vs 64 vs143 vs 272	—	Italian	Minimum age 90	ADA*2	non-ADA*2	Candidate Region/Gene	20174870
rs1800629	TNF	—	0.019	747	—	Italian	19-110	A	G	Candidate Region/Gene	18511747
rs1800795	IL-6	—	0.018	285	—	Finn	90-95	C	G	Candidate Region/Gene	15664628
rs1800871	IL-10	—	0.0026	500	—	Japanese	56.7 years; range, 19–100 years	TC	TT	Candidate Region/Gene	16424284
IL6 VNTR A/B/C/D	—	0.56	0.05	61 vs 94	—	Italian	Mean age 100	B	non-B	Candidate Region/Gene	17506774
G477T	SIRT3	—	0.0272	801	—	Italian	120 subject aged 100 or older	GT	TT	Candidate Region/Gene	14580859
AAT M/Z/S	AAT	0.18	1e-07	143 vs 255 vs 127	—	Italian	Centenarians	M, S	Z	Candidate Region/Gene	17048073
rs2866164	MTP	—	0.05	205 vs 288	—	Ashkenazi Jewish	Mean age 97	non-CC	CC	Candidate Region/Gene	22496539
rs1805097	IRS2	2.03	0.0003	144 vs 418	—	Italian	85-100 years old	non-AA	AA	Candidate Region/Gene	19887537
APOA1-MspI-RFLP A/P alleles	APOA1	—	0.045	413 vs. 571	—	Italian	median age 101	A	P	Candidate Region/Gene	12556235
3p24-22	3p24-22	—	0.037	3953	—	American	Minimum age 98	—	—	Genome-Wide Association Study	20824210
rs1801133	MTHFR	—	0.06	564 vs. 374	—	French	mean age 100.71	TT	CT, CC	Candidate Region/Gene	9106548
192/55 loci	PON1	—	0.01	579 vs 308	—	Italian	Over 100	—	R+M+	Candidate Region/Gene	12082503
STR variation	CSF1TPO	—	0.003	60 vs 250	—	Chinese	>90	low variation in STRs	high variation in STRs	-	20582731
rs4340	ACE	1.90	0.001	300 vs 160	—	French	100+	I	D	Candidate Region/Gene	8136829
rs429358 + rs7412	APOE	—	0.04	1236 vs 326	—	Chinese	60+	e4	non-e4	Candidate Region/Gene	9792194
rs4340	ACE	—	0.001	301 vs 172	—	Croatian	mean age 88.2	I	D	Candidate Region/Gene	21614448

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25 of 1027 variants

Longevity DB

Genetic variants implicated in human longevity.

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