Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
rs2542052 APOC3 — 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
rs5882 CETP — 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
APOE4 APOE — 0.71 106 vs 349 — American 70-79 (duration of study - 7 years) e4 — Candidate Region/Gene 16799145
ASP299GLY TLR4 — 0.04 8 vs 8 — Italian 25-50 — — — 16803999
82133GNA PLXNA1 — 0.0189 26 vs 27 — Japanese 60-69, 90-99, >100 — — — 15820493
DR7 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
DR11 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
DR13 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90+ apoE4 — Candidate Region/Gene 11780357
mtDNA haplotype — — 0.0052 212 vs 275 — Italian 100+ non-J haplogroups — Mitochondrial Haplogroup 10463944
Met410Val SHC1 — 0.192 730 563 Human 85+ Met — Candidate Region/Gene 15036421
Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
mt146 C>T — — 0.005 113 (cases) vs 200 — Chinese 90-110 mt146T mt146C Complete Mitochondrial Genome 22729909
2437 T>C HSPA1L — 0.01 129 vs 100 — Irish 80–97 2437C — Candidate Region/Gene 12742533
rs4646994 ACE — 0.04 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals — Chinese Old: 59-70, Very old 90-113 I (insertion) — Candidate Region/Gene 11773214
rs2542052 APOC3 — 0.0001 213 old vs 216 offspring vs 258 controls — Ashkenazi Jewish 100+ A — Candidate Region/Gene 16602826
rs2476601 PTPN22 — 0.663 225 vs 278 — Italian Mean age 93 — — Candidate Region/Gene 21113673
rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
rs5882 CETP — 0.318 175 vs 189 — Italian 99.6 — — Candidate Region/Gene 15888337
(+)2019 del ADIPOQ10 — 0.05 118 centenarians vs 78 unrelated young — Ashkenazi Jewish 95-105 A Del/Del Candidate Region/Gene 18511746
rs2069827 IL6 — 0.064 1,089 vs 736 563 (longtitudinal study) Danish, Dutch 92+ Danish, 85+ Dutch A — — 22234866
rs2060793 CYP2R1 — 0.04 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) A — Candidate Region/Gene 23128285
rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
rs3829251 NADSYN1 — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
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  • 25 of 1635 variants