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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
African European (1)
Australian (3)
Canadian (1)
Finn (14)
Georgian (4)
Human (3)
Sichuan (18)
Spanish (4)
American (46)
African American (2)
Mexican (1)
Tunisian (1)
Turkish (3)
Asian (1)
Chinese (70)
Japanese (59)
Okinawan (4)
Korean (1)
Brazilian (2)
Caucasian (82)
European (4)
British (20)
Polish (14)
Croatian (1)
Danish (83)
Dutch (16)
French (17)
German (102)
Greek (9)
Irish (15)
Italian (180)
Calabrian (1)
Calabrian (8)
Bulgarian (7)
Swiss (1)
Spaniard (10)
Hispanic (1)
Ashkenazi Jewish (36)
Jordanian (8)
Russian (4)
Tatar (1)
Study type:
+
-
Candidate Region/Gene «
Variant type:
+
-
SNP (375)
Locus (3)
Haplotype (53)
Other (1)
STR (11)
Deletion (5)
CNV (1)
(1)
VNTR (1)
Variant effect:
+
-
Longevity‑Associated (344)
No Age Effect (382)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
APOE4
APOE
—
0.013
35 vs 125
—
Chinese
90 years or over
High E4 frequency
—
Candidate Region/Gene
11780357
APOE4
APOE
—
0.71
106 vs 349
—
American
70-79 (duration of study - 7 years)
e4
—
Candidate Region/Gene
16799145
apoE haplotypes
APOE
—
0.013
35 old vs 71 young vs 54 MI patients
—
Chinese
90+
apoE4
—
Candidate Region/Gene
11780357
Met410Val
SHC1
—
0.192
730
563
Human
85+
Met
—
Candidate Region/Gene
15036421
Apo C-I 1>2
Apo C-I
—
0.05
282 vs 200
—
British
84+
Apo C-I 2
—
Candidate Region/Gene
9105559
2437 T>C
HSPA1L
—
0.01
129 vs 100
—
Irish
80–97
2437C
—
Candidate Region/Gene
12742533
rs4646994
ACE
—
0.04
227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals
—
Chinese
Old: 59-70, Very old 90-113
I (insertion)
—
Candidate Region/Gene
11773214
rs2542052
APOC3
—
0.0001
213 old vs 216 offspring vs 258 controls
—
Ashkenazi Jewish
100+
A
—
Candidate Region/Gene
16602826
rs2476601
PTPN22
—
0.663
225 vs 278
—
Italian
Mean age 93
—
—
Candidate Region/Gene
21113673
rs1801133
MTHFR
—
0.01
108 (patients with CVD) vs 118
—
Swiss
>65
C
—
Candidate Region/Gene
10583447
rs5882
CETP
—
0.318
175 vs 189
—
Italian
99.6
—
—
Candidate Region/Gene
15888337
(+)2019 del
ADIPOQ10
—
0.05
118 centenarians vs 78 unrelated young
—
Ashkenazi Jewish
95-105
A
Del/Del
Candidate Region/Gene
18511746
rs2060793
CYP2R1
—
0.04
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
A
—
Candidate Region/Gene
23128285
rs2282679
GC
—
0.6
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
—
—
Candidate Region/Gene
23128285
rs3829251
NADSYN1
—
0.6
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
—
—
Candidate Region/Gene
23128285
rs132793
XRCC6
—
0.74
224 vs 293
170 vs 220
Caucasian
,
European
90-103, 98+ (replication)
—
—
Candidate Region/Gene
21972126
rs1008438
HSPA1A
—
0.005
157 vs 62
—
Danish
92.8
A
—
Candidate Region/Gene
16804002
rs1061581
HSPA1B
—
0.04
157 vs 62
—
Danish
92.8
A
—
Candidate Region/Gene
16804002
−174 G/C
Interleukin 6
—
0.6
2224
—
American
,
Caucasian
65+
G
—
Candidate Region/Gene
15939070
−455 G/A
FGB
—
0.56
2224
—
American
,
Caucasian
65+
—
—
Candidate Region/Gene
15939070
rs2234693
ESR1
—
0.08
108 vs 85
—
Italian
90+
PP (genotype)
—
Candidate Region/Gene
20819792
rs1800795
IL6
—
0.006
244 vs 309
138 vs 98
Italian
85+
CC (genotype)
—
Candidate Region/Gene
19377912
apoE haplotypes
—
—
0.02
80 vs 391
—
Greek
80+
Apo e4
—
Candidate Region/Gene
17234815
?60H
LMP2
—
0.756
157 vs 311
—
Italian
88+
H
—
Candidate Region/Gene
11772516
?145K
LMP7
—
0.849
157 vs 311
—
Italian
88+
K
—
Candidate Region/Gene
11772516
Page 1 of 32
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25 of 784 variants
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