Longevity DB

Genetic variants implicated in human longevity.

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polymorphism	factor	odds ratio	pvalue	initial number	replication number	Population	age of cases	shorter lived allele	longer lived allele	study type	reference
3p22-24 region	3p22-24 region	—	0.09	325 vs 160	—	Northern European	86 - 109	—	—	Whole-Genome Linkage Scan	22506048
rs2838809	ADARB1	0.27	0.0096	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs2838816	ADARB1	0.28	0.0116	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs17294019	ADARB2	0.69	0.0005	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA/AG	—	—	20011587
rs414743	ADARB1	0.72	0.0001	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA/AG	—	—	20011587
rs1533484	ADARB2	0.81	0.0109	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA/AG	—	—	20011587
rs2676192	ADARB2	0.81	0.0096	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs2805533	ADARB2	0.91	0.1904	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA/AG	—	—	20011587
rs2387653	ADARB2	1.17	0.1053	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs884949	ADARB2	1.19	0.0911	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs2805562	ADARB2	1.22	0.05	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs2805543	ADARB2	1.23	0.0055	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs3788157	ADARB1	1.23	0.0075	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs10903420	ADARB2	1.28	0.0048	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs1007147	ADARB2	1.35	0.0015	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs2805535	ADARB2	1.36	0.0249	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs2387952	ADARB2	1.37	0.0004	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs3898610	ADARB2	1.42	0.0015	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA	—	—	20011587
rs2838810	ADARB1	3.71	0.0136	877 vs 1808	Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538.	Northern European	96–119 (median: 103)	AA/AG	—	—	20011587

19 variants