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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2866164 MTP 0.05 205 vs 288 Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
Ile119Val PCMT1 0.049 40 vs 40 Ashkenazi Jewish Mean age 87.2 Candidate Region/Gene 10496068
rs2866164 MTTP 0.05 126 vs 288 Ashkenazi Jewish median age = 97 CG/GG Candidate Region/Gene 22496539
rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish mean age 98.2 A Candidate Region/Gene 16602826
rs2542052 APOC3 0.001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish 100+ A Candidate Region/Gene 16602826
rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
rs1801133 MTHFR 0.029 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 C Candidate Region/Gene 15621215
rs9536314 KL 0.007 216 vs 309 Ashkenazi Jewish >95 TG (genotype) Candidate Region/Gene 15677572
rs4880 SOD2 0.009 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 T Candidate Region/Gene 15621215
A/G IGF2 0.063 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 A, AA Candidate Region/Gene 15621215
rs5882 CETP 0.05 300 vs 320 vs 258 Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
CTSD CTSD 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
ApaI IGF2 0.063 224 vs 441 Ashkenazi Jewish 75 G A Candidate Region/Gene 15621215
rs4880 SOD2 0.009 224 vs 441 Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
R353Q F7 0.045 224 vs 441 Ashkenazi Jewish 75 A G Candidate Region/Gene 15621215
AGT AGT 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
TP53 TP53 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
DRD4 DRD4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
SLC6A4 SLC6A4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
rs1043618 HSP70-A1A 1.0 347 vs 238 American, Ashkenazi Jewish Minimum age 100 Candidate Region/Gene 17027907
rs6457452 HSP70-A1B 1.0 347 vs 238 American, Ashkenazi Jewish Minimum age 100 Candidate Region/Gene 17027907
(+)2019 del ADIPOQ10 0.05 118 centenarians vs 78 unrelated young Ashkenazi Jewish 95-105 A Del/Del Candidate Region/Gene 18511746
rs429358, rs7412 APOE 0.025 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
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  • 25 of 38 variants