Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs5882 CETP — 0.05 300 vs 320 vs 258 — Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
(+)2019 del ADIPOQ10 — 0.05 118 centenarians vs 78 unrelated young — Ashkenazi Jewish 95-105 A Del/Del Candidate Region/Gene 18511746
A/G IGF2 — 0.063 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — A, AA Candidate Region/Gene 15621215
ApaI IGF2 — 0.063 224 vs 441 — Ashkenazi Jewish 75 G A Candidate Region/Gene 15621215
rs5882 CETP — 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
rs10149689 TSHR 1.22 0.08 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
CTSD CTSD — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
AGT AGT — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
TP53 TP53 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
DRD4 DRD4 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
SLC6A4 SLC6A4 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
rs1043618 HSP70-A1A — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
rs6457452 HSP70-A1B — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907