polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
rs11040489 | KRTAP5-6 | — | 0.005869 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
rs6911407 | FOXO3 | 1.28 | 0.006 | 388 vs 371 | 535 vs 553 | German | mean age 98.4 years | — | — | Candidate Region/Gene | 19196970 |
rs2802288 | FOXO3 | 1.28 | 0.006 | 388 vs 371 | 535 vs 553 | German | mean age 98.4 years | — | — | Candidate Region/Gene | 19196970 |
rs768023 | FOXO3 | 1.27 | 0.007 | 388 vs 371 | 535 vs 553 | German | mean age 98.4 years | — | — | Candidate Region/Gene | 19196970 |
rs800140 | TSPAN32 | — | 0.0081 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
rs1776180 | EXO1 | 1.39 | 0.01 | 395 vs 411 | 455 vs 109 | French, German | Mean age 101.3 | G | C | Candidate Region/Gene | 19698732 |
rs2802290 | FOXO3 | 1.26 | 0.01 | 388 vs 371 | 535 vs 553 | German | mean age 98.4 years | — | — | Candidate Region/Gene | 19196970 |
rs4930001 | DEAF1 | — | 0.010851 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
rs2301582 | NALP1 | 1.30 | 0.011 | 386 vs 410 | 541 vs 469 | German | 100 to 110, mean age = 101.3 | C | — | Candidate Region/Gene | 20800603 |
rs12770830 | HSPA14 | 1.35 | 0.011 | 1,089 vs 736 | 1,613 vs 1,104 | Danish, German | 92-93 Danish, 95–110 German | — | — | — | 22234866 |
rs648802 | PERP | 1.29 | 0.012 | 386 vs 410 | 541 vs 469 | German | 100 to 110, mean age = 101.3 | C | — | Candidate Region/Gene | 20800603 |
rs769449 | APOE | 0.70 | 0.018 | 1,089 vs 736 | 1,613 vs 1,104 | Danish, German | 92-93 Danish, 95–110 German | G | — | — | 22234866 |
rs13220810 | FOXO3 | 0.78 | 0.02 | 388 vs 371 | 535 vs 553 | German | mean age 98.4 years | — | — | Candidate Region/Gene | 19196970 |
rs1268170 | FOXO3 | 1.24 | 0.02 | 388 vs 371 | 535 vs 553 | German | mean age 98.4 years | — | — | Candidate Region/Gene | 19196970 |
rs11188059 | CYP2C | — | 0.04 | 616 centenarians versus control group of 945 younger individuals | — | German | — | — | — | Candidate Region/Gene | 21798861 |
rs473268 | FOXO3 | 1.21 | 0.044 | 388 vs 371 | 535 vs 553 | German | mean age 98.4 years | — | — | Candidate Region/Gene | 19196970 |
- | HRAS1 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | 1 (specifically for SIRT3 in a French population) | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | TH | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | INS | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | IGF2 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
rs4073591 | — | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
rs4073590 | DEAF1 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
rs11040489 | KRTAP5-6 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
rs4930001 | — | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
rs800140 | TSPAN32 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |