Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs6589722 — — 0.015 209 vs 402 — Japanese 95+ — — Candidate Region/Gene 23770741
rs3745548 INSR — 0.057 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs266729 ADIPOQ10 — 0.08 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs17356414 JUN — 0.082 212 vs 401 — Japanese 95+ — — Candidate Region/Gene 23770741
rs2252673 INSR — 0.083 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs12786104 CBL — 0.12 210 vs 398 — Japanese 95+ — — Candidate Region/Gene 23770741
rs10811661 — — 0.13 213 vs 402 — Japanese 95+ — — Candidate Region/Gene 23770741
rs3779501 PIK3CG — 0.139 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs2511837 CBL — 0.14 212 vs 398 — Japanese 95+ — — Candidate Region/Gene 23770741
rs3215173 SHC1 1.60 0.15 230 vs 180 — Japanese Mean age 100.8 +/- 1.5 G/- — Candidate Region/Gene 14530863
rs1776180 EXO1 — 0.16 206 vs 401 — Japanese 95+ — — Candidate Region/Gene 23770741
rs3745546 INSR — 0.168 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs1815274 JUN — 0.18 212 vs 401 — Japanese 95+ — — Candidate Region/Gene 23770741
rs1063539 ADIPOQ10 — 0.2 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs1799817 INSR — 0.205 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs182052 ADIPOQ10 — 0.22 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs2288404 INSR — 0.277 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs2999131 — — 0.31 208 vs 391 — Japanese 95+ — — Candidate Region/Gene 23770741
rs1801278 IRS1 — 0.337 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs2305268 PIK3CB — 0.363 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs3751436 FOXO1A — 0.369 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs6519194 ATF4 — 0.41 206 vs 397 — Japanese 95+ — — Candidate Region/Gene 23770741
rs11074359 COQ7 — 0.43 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs10823112 SIRT1 — 0.44 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs3745544 INSR — 0.441 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
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  • 25 of 49 variants