Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4537545 IL6R — 3e-18 308 — American, European, Ashkenazi Jewish 75.7 — — Candidate Region/Gene 19249341
rs1528753 — — 8.1e-08 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
HRAS1 LASS1 (CGT) APOE — 6.91e-07 204 vs 251 — American — — — Candidate Region/Gene 20569235
HRAS1 LASS1 (CGT) APOE — 1e-06 79 vs 88 — American — — — Candidate Region/Gene 20569235
rs10493513 — — 1.5e-06 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs2371208 — — 2.6e-06 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs10493514 — — 2.8e-06 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs10496799 NXPH2 — 1.4e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs6689491 — — 2e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs10493515 — — 2.3e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs10489006 — — 3.6e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs10493518 — — 3.6e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs10493517 — — 4.2e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs6657082 — — 5.5e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs3757354 MYLIP — 6.4e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs10498263 OR4Q3 — 8.3e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
HRAS1 LASS1 (CCT) APOE — 9.5e-05 204 vs 251 — American — — — Candidate Region/Gene 20569235
rs1915501 — — 0.00011 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs1405051 — — 0.00014 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs6459623 IBRDC2 — 0.00015 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
HRAS1 LASS1 (CCT) APOE — 0.00197 125 vs 163 — American — — — Candidate Region/Gene 20569235
−438 G/A TAFI 0.53 0.003 2224 — American, Caucasian 65+ G (men) — Candidate Region/Gene 15939070
HRAS1 LASS1 (CCT) APOE — 0.0511 68 vs 68 — American — — — Candidate Region/Gene 20569235
rs3764650 ABCA7 — 0.135 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs610932 MS4A6A — 0.176 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
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  • 25 of 33 variants