Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs1800591 MTTP — 0.032 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs662 PON1 1.06 0.11 — — Danish, Dutch, French, German, Italian, Tatar >/=80 — — Candidate Region/Gene 20362697
rs61733139 MTTP — 0.32 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
(rs429358, rs7412) + (rs2075650) APOE + TOMM40 0.93 0.337 403 vs 1670 3746 vs 5912 Dutch Mean age 94 e4 + G — Genome-Wide Association Study 21418511
rs61733139 MTTP — 0.43 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
rs1800591-rs61733139 MTTP — 0.46 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
rs61733139 MTTP — 0.57 379 vs 251 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
rs1800591 MTTP — 0.6 379 vs 251 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs1800591-rs61733139 MTTP — 0.61 197 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs1800591 MTTP — 0.64 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
Cdx2-GATA haplotype 1 allele Vitamin D receptor — 0.78 935 participants — Dutch mean age = 75.7 years — — Candidate Region/Gene 21051524
rs1800591-rs61733139 MTTP — 0.93 164 vs 261 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
  • 14 variants