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| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs4420638 | APOE | 0.72 | 3.4e-36 | 7729 vs 16121 | 13060 vs 61156 | European | 90+ | — | — | GWAS | 24688116 |
| rs2149954 | — | 1.10 | 1.74e-08 | 7729 vs 16121 | 13060 vs 61156 | European | 90+ | — | — | GWAS | 24688116 |
| DRD4 7R allele | DRD4 | — | 3.5e-08 | 310 vs 2909 | — | European | mean age 95.2 years | — | — | Candidate Region/Gene | 23283341 |
| rs4420638 | APOE | — | 9.6e-08 | 4445 total (each a part of sibship of 2-5 siblings) | — | Caucasian, European | 90 | — | — | Genome-Wide Association Study | 23286790 |
| - | Insulin signaling pathway (IIS) | — | 0.01 | 403 vs 1670 | — | European | 90-103 | — | — | Genome-Wide Association Study | 22113349 |
| - | Telomere maintenance pathway (TM) | — | 0.02 | 403 vs 1670 | — | European | 90-103 | — | — | Genome-Wide Association Study | 22113349 |
| marker D4S1564 | — | — | 0.044 | 308 | — | European | min. age 98 for one sibling. 91+ males, 95+ females | — | — | Genome-Wide Association Study | 11526246 |