Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (153)   No Age Effect (209)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1800896 IL10 — 0.64 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800629 TNF — 0.76 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs4073591 DEAF1 — 0.002618 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs4073590 DEAF1 — 0.004259 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs4930001 DEAF1 — 0.010851 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs800140 TSPAN32 — 0.0081 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs16928120 — — 0.00057 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs1800591 MTTP — 0.032 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
    rs61733139 MTTP — 0.32 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
    rs1061581 HSPA1B — 0.05 191 vs 53 — Chinese >90 A G Candidate Region/Gene 19840767
    rs2227956 HSPA1L — 0.01 191 vs 53 — Chinese >90 TC TT/CC Candidate Region/Gene 19840767
    rs1801133 MTHFR — 0.727 130 vs 135 — Jordanian Mean age 90.01 — — Candidate Region/Gene 20003469
    rs9340799 ESR1 — 0.22 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    rs2275075 LMNA — 0.54 873 vs 443 New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    HRAS1 LASS1 (CCT) APOE — 4.1e-05 147 vs 188 — Georgian — — — Candidate Region/Gene 20569235
    rs2227956 HSPA1L — 0.328 168 cases — Danish Mean age 92.8 +/- 0.4 — — Candidate Region/Gene 20388090
    rs1800795 IL-6 — 0.007 323 (cases) vs 377 (initial) — Italian median age = 101 G C Candidate Region/Gene 11500818
    rs1800795 IL6 — 0.01 1710 total — Danish 47-100 C G Candidate Region/Gene 15130757
    rs1801282 PPARG — 0.035 222 vs 250 — Caucasian 86 to 109; median age 99 G — Candidate Region/Gene 15236769
    rs2297626 FOXO1A — 0.512 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2297627 FOXO1A — 0.495 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745544 INSR — 0.441 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745546 INSR — 0.168 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745548 INSR — 0.057 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2252673 INSR — 0.083 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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