Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (153)   No Age Effect (209)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 Italian, Spaniard 100–111 K — Candidate Region/Gene 23354683
    rs6457452 HSP70-A1B — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
    rs4073591 DEAF1 — 0.002618 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs4073590 DEAF1 — 0.004259 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs800140 TSPAN32 — 0.0081 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs16928120 — — 0.00057 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs1801282 PPARG — 0.035 222 vs 250 — Caucasian 86 to 109; median age 99 G — Candidate Region/Gene 15236769
    rs1805097 IRS2 2.07 0.04 144 vs 418 — Caucasian 85 to 104, mean age = 96 ± 4 C — Candidate Region/Gene 19887537
    rs7843014 PTK2 — 1.0 79 vs 316 — Italian 100-104 — — Candidate Region/Gene 24930376
    rs7460 PTK2 — 1.0 79 vs 316 — Italian 100-104 — — Candidate Region/Gene 24930376
    rs7843014 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376
    rs7460 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376
    rs12978931 PVRL2 1.15 0.0445 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs519825 PVRL2 1.28 0.01577 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs419010 PVRL2 1.13 0.091 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs4803766 PVRL2 0.97 0.708 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs11879589 PVRL2 1.67 0.07601 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs395908 PVRL2 0.81 0.048 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs519113 PVRL2 0.90 0.3734 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs6857 PVRL2 0.90 0.518 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs10119 TOMM40 0.94 0.914 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs449647 APOE 1.01 0.767 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs405509 APOE 1.18 0.027 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs440446 APOE 1083.00 0.509 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs769448 APOE 1.09 0.66 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    • Page 1 of 15
    • 25 of 375 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue