Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (153)   No Age Effect (209)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs662 PON1 1.06 0.33 — — Irish >/=80 — — Candidate Region/Gene 20362697
    rs662 PON1 1.06 0.11 — — Danish, Dutch, French, German, Italian, Tatar >/=80 — — Candidate Region/Gene 20362697
    rs662 PON1 1.03 0.55 — — Irish >/=100 — — Candidate Region/Gene 20362697
    rs4673 — 1.48 0.022 — — Russian — C T Candidate Region/Gene 23755540
    rs3814314 LMNA — 0.017 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs11578696 LMNA — 0.21 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) Mean age 101.5 — — Candidate Region/Gene 22340368
    rs4661146 LMNA — 0.12 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs1801133 MTHFR — 0.029 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — C Candidate Region/Gene 15621215
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young — Italian 91+, 73-91 P — Candidate Region/Gene 23125046
    rs3772190 TERC — 0.006 1013 total — Danish — A G Candidate Region/Gene 22136229
    rs12696304 TERC — 0.248 1013 total — Danish — — — Candidate Region/Gene 22136229
    rs1800775 CETP — 0.02 10261 — Danish 20-93, followed for up to 34 years CC non-CC Candidate Region/Gene 23083790
    rs708272 CETP — 0.02 10261 — Danish 20-93, followed for up to 34 years GG non-GG Candidate Region/Gene 23083790
    rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
    rs2107538 RANTES 3.20 0.029 104 vs 110 — Spaniard Mean age 89.4 A G Candidate Region/Gene 22265023
    rs2280789 RANTES 8.80 0.03 104 vs 110 — Spaniard Mean age 89.5 C T Candidate Region/Gene 22265023
    rs1937 TFAM — 0.003 107 vs 284 — Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
    rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
    rs4646 CYP19 1.90 0.04 108 vs 85 — Italian 90+ — T Candidate Region/Gene 20819792
    rs2234693 ESR1 — 0.08 108 vs 85 — Italian 90+ PP (genotype) — Candidate Region/Gene 20819792
    rs9340799 ESR1 — 0.22 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    rs10047589 TXNRD1 1.46 0.043 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up G — Candidate Region/Gene 22406557
    rs207444 XDH — 0.046 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up G - Unsure — Candidate Region/Gene 22406557
    rs26802 GHRL 2.34 0.032 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A — Candidate Region/Gene 22406557
    • Page 1 of 15
    • 25 of 375 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue