Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (153)   No Age Effect (209)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1333049 — 0.64 0.001 80 (cases) vs 258 healthy young — Human 100–104 C — Candidate Region/Gene 20230275
    rs16928120 — — 0.00057 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs4746720 — 1.35 0.022 246 vs 236 — Chinese 60-90 — C Candidate Region/Gene 20633545
    rs7843014 — 0.37 0.001 175 vs 355 — Spanish 100-111 A C Candidate Region/Gene 24930376
    rs4420638 — 0.85 0.176 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs1800624 — — 0.028 28 vs 56 — Caucasian 90+ non-AA AA Candidate Region/Gene 24284407
    rs13306703 — — 0.764 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    rs1048310 — — 0.87 208 vs 399 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs6589722 — — 0.015 209 vs 402 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs10811661 — — 0.13 213 vs 402 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs2999131 — — 0.31 208 vs 391 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs4673 — 1.48 0.022 — — Russian — C T Candidate Region/Gene 23755540
    rs1879417 — — 0.018 321 vs 442 — Italian 89-107 — — Candidate Region/Gene 23572278
    rs10459953 — — 0.522 321 vs 442 — Italian 89-107 — — Candidate Region/Gene 23572278
    rs10277237 — — 0.805 321 vs 442 — Italian 89-107 — — Candidate Region/Gene 23572278
    rs1799990 — — 1.0 150 vs 165 — Polish Centenarian — — Candidate Region/Gene 23406923
    rs429358, rs7412 APOE 0.43 0.0006 114 vs 2071 — Irish >90 e4 e2 Candidate Region/Gene 11470126
    HRAS1 LASS1 (CCT) APOE — 4.1e-05 147 vs 188 — Georgian — — — Candidate Region/Gene 20569235
    rs429358, rs7412 APOE 0.75 0.005 2307 vs 764 — American, Danish Mean age 60.2 e4 e2 Candidate Region/Gene 23040522
    rs2075650 APOE — 0.000527 1364 — American, British Age range 50-108; mean age at death 80.2 C T Candidate Region/Gene 22445811
    rs449647 APOE 1.01 0.767 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs405509 APOE 1.18 0.027 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs440446 APOE 1083.00 0.509 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs769448 APOE 1.09 0.66 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    rs769449 APOE 0.90 0.62 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
    • Page 1 of 15
    • 25 of 375 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue