Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (153)   No Age Effect (209)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    XbaI APOB 1.30 0.03 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 — X+X+ Candidate Region/Gene 17393087
    rs2227956 HSPA1L — 0.01 191 vs 53 — Chinese >90 TC TT/CC Candidate Region/Gene 19840767
    rs1061170 CFH 1.78 0.005 491 with follow-up during 4 years — Finn >90 — TT Candidate Region/Gene 19000922
    rs4646 CYP19 1.90 0.04 108 vs 85 — Italian 90+ — T Candidate Region/Gene 20819792
    rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    rs2241766 ADIPQO — 0.164 110 vs 120 — Jordanian mean age 90.2 years G T Candidate Region/Gene 20201642
    rs2280789 RANTES 8.80 0.03 104 vs 110 — Spaniard Mean age 89.5 C T Candidate Region/Gene 22265023
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    rs1631685 NPC1 — 0.026 152 vs 120 — Polish >100 C T Candidate Region/Gene 18834923
    rs2075650 APOE — 0.000527 1364 — American, British Age range 50-108; mean age at death 80.2 C T Candidate Region/Gene 22445811
    rs7460 PTK2 0.40 0.001 175 vs 355 — Spanish 100-111 A T Candidate Region/Gene 24930376
    rs11555236 SIRT3 — 0.03 357 — Italian 70+ — T Candidate Region/Gene 23839864
    rs4673 — 1.48 0.022 — — Russian — C T Candidate Region/Gene 23755540
    rs6166 FSHR 4.21 0.036 114 vs 173 — Italian >/=90 Asn Ser Candidate Region/Gene 22985084
    rs662 PON1 — 0.04 1265 vs 582 541 total Danish 93 R Q Candidate Region/Gene 15241482
    rs1801282 PPARG 0.13 0.03 114 vs 173 — Italian >/=90 Pro/Ala Pro/Pro, Ala/Ala Candidate Region/Gene 22985084
    rs708272 CETP — 0.02 10261 — Danish 20-93, followed for up to 34 years GG non-GG Candidate Region/Gene 23083790
    rs1800775 CETP — 0.02 10261 — Danish 20-93, followed for up to 34 years CC non-CC Candidate Region/Gene 23083790
    rs11039149 NR1H3 — 0.015 599 — Dutch 85 years haplotype 1 haplotype 2 Candidate Region/Gene 17452725
    rs5882 CETP 3.56 0.001 213 vs 258 — Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
    rs1800896 IL10 3.10 0.0003 142 vs 153 — Mean age 67 AA GG Candidate Region/Gene 15466015
    rs5882 CETP — 0.05 300 vs 320 vs 258 — Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
    rs1800896 IL10 — 0.019 174 vs 227 — Italian >100 — GG Candidate Region/Gene 12676903
    rs9282861 SULT1A1 — 0.017 68 vs 49 — American, Caucasian 70-99 — GG Candidate Region/Gene 9854023
    rs7799039 LEP — 0.048 128 vs 414 — Polish 100+ — GG Candidate Region/Gene 24549597
    • Page 1 of 15
    • 25 of 375 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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