Denigma

Longevity Variant Database

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    ‑ (19)   Candidate Region/Gene (382)   Meta‑Analysis (8)   Genome‑Wide Association Study (103)   Mitochondrial Haplogroup (27)  
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    SNP (314)   Haplotype (43)   Other (1)   STR (7)   Deletion (1)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1610601 — 0.68 1.98e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    rs1633063 — 0.68 3.82e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    rs11790055 — 1.38 1.49e-05 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    rs10959258 — 1.36 1.86e-05 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    rs9595687 — 0.49 2.09e-05 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    rs1575892 — 0.45 9.32e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    rs16947526 — 0.56 1.23e-05 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    rs158869 — 1.37 4.98e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    rs350450 — 0.69 6.34e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
    APOE e2,e3,e4 APOE — 0.05 185 vs 486 — Finn Over 100 E4 e2 Candidate Region/Gene 8018664
    rs708272 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    rs5882 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    I carriers of ACE — — 0.045 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
    rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
    ASP299GLY TLR4 — 0.04 8 vs 8 — Italian 25-50 — — — 16803999
    rs147610191 APOA4 — 0.05 229 vs 571 — Calabrian 81–109 (median 101) — — Candidate Region/Gene 12556235
    APOC3-SstI-RFLP (3'UTR, 3238 nt) APOC3 — 0.05 229 vs 571 — Calabrian 81–109 (median 101) — — Candidate Region/Gene 12556235
    −438 G/A TAFI 0.53 0.003 2224 — American, Caucasian 65+ G (men) — Candidate Region/Gene 15939070
    - GSTM1 — 0.74 94 vs 418 — Italian 100 years vs 46 years — — - 11162685
    H63D HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    S65C HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
    rs3745548 INSR — 0.057 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2252673 INSR — 0.083 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3779501 PIK3CG — 0.139 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745546 INSR — 0.168 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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