Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    No Age Effect « 
  • Study type: + -
    Candidate Region/Gene (209)   Meta‑Analysis (7)   Genome‑Wide Association Study (97)   Mitochondrial Haplogroup (1)  
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
    rs1801274 FCGR2A — 0.05 408 vs 446 vs 454 — German 100–110/ mean101.3 (SNP is His/Arg) — Candidate Region/Gene 16893392
    rs2853826 MT-ND3 — 0.219 98 vs 117 — Chinese 90–100 A — Candidate Region/Gene 18759861
    rs2227956 HSPA1L — 0.328 168 cases — Danish Mean age 92.8 +/- 0.4 — — Candidate Region/Gene 20388090
    rs9340799 ESR1 — 1.0 148 vs 414 — Polish mean age 101.1 — — Candidate Region/Gene 20599431
    rs1801133 MTHFR — 0.727 130 vs 135 — Jordanian Mean age 90.01 — — Candidate Region/Gene 20003469
    rs1800629 TNF — 1.0 174 vs 224 — Italian >100 — — Candidate Region/Gene 12676903
    rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
    rs1800587 IL1A — 0.31 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs16944 IL1B — 0.08 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1143634 IL1B — 0.53 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800795 IL6 — 0.23 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800896 IL10 — 0.64 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800629 TNF — 0.76 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    mt9055A mtDNA — 0.164 129 vs 100 — Irish 80-97 — — Mitochondrial Haplogroup 11404057
    rs3745548 INSR — 0.057 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2252673 INSR — 0.083 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3779501 PIK3CG — 0.139 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745546 INSR — 0.168 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs1799817 INSR — 0.205 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2288404 INSR — 0.277 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs1801278 IRS1 — 0.337 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs2305268 PIK3CB — 0.363 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3745544 INSR — 0.441 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs8192678 PPARGC1A — 0.469 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    • Page 1 of 13
    • 25 of 314 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue