Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    - TH — 0.045 202 vs 170 vs 82 — Italian 100-105 (oldest of 3 age groups, see notes) — — Candidate Region/Gene 11053670
    marker D4S1564 — — 0.044 308 — European min. age 98 for one sibling. 91+ males, 95+ females — — Genome-Wide Association Study 11526246
    rs201058276 F7 0.68 0.01 187 vs 201 — Danish centenarians R — Candidate Region/Gene 11602206
    323ins10 F7 0.69 0.01 187 vs 201 — Danish centenarians 323P0 — Candidate Region/Gene 11602206
    3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) HRAS 1.13 0.002 234 vs 467 — Italian centenarians a3 allele (see notes) — Candidate Region/Gene 11943467
    APOA1-MspI-RFLP (−75) APOA1 — 0.016 229 vs 571 — Calabrian 81–109 (median 101) A (=Absence) — Candidate Region/Gene 12556235
    (A/C)−110 HSP70-1 0.40 0.005 120 vs 471 — Italian 100 years and above A — Candidate Region/Gene 14501185
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    rs2764264 FOXO3 — 0.0002 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs13217795 FOXO3 — 0.0006 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs2802292 FOXO3 — 0.0001 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs4880 SOD2 0.91 0.002 1650 — Danish All danes born in 1905 (Danish 1905 cohort) T — Candidate Region/Gene 19428448
    rs1050450 GPX1 0.93 0.008 1613 — Danish All danes born in 1905 (Danish 1905 cohort) C — Candidate Region/Gene 19428448
    rs1935949 FOXO3A 1.46 0.019 299 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 114 T — Candidate Region/Gene 19489743
    rs2153960 FOXO3A 1.16 0.019 300 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 115 — — Candidate Region/Gene 19489743
    rs3778588 FOXO3A 1.22 0.023 301 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 116 — — Candidate Region/Gene 19489743
    rs4946935 FOXO3A 1.48 0.018 302 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 117 A — Candidate Region/Gene 19489743
    rs12153009 GHR 0.87 0.033 305 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 120 — — Candidate Region/Gene 19489743
    rs2940923 GHR 1.21 0.0013 306 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 121 — — Candidate Region/Gene 19489743
    rs2940935 GHR 1.24 0.0031 307 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 122 — — Candidate Region/Gene 19489743
    rs2272037 IGF1R 1.19 0.021 316 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 131 — — Candidate Region/Gene 19489743
    rs3758391 SIRT1 1.45 0.026 246 vs 236 — Chinese 71.2±7.1 years T — Candidate Region/Gene 20633545
    rs4746720 SIRT1 1.35 0.022 246 vs 236 — Chinese 71.2±7.1 years T — Candidate Region/Gene 20633545
    rs770087 DUSP6 1.53 0.002 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C — Candidate Region/Gene 20800603
    rs2301582 NALP1 1.30 0.011 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C — Candidate Region/Gene 20800603

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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