Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (243)   No Age Effect (314)  
  • Study type: + -
    GWAS (2)   ‑ (1)   Candidate Region/Gene (375)   Meta‑Analysis (37)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (147)   Mitochondrial Haplogroup (1)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1008438 HSPA1A 3.86 0.016 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs1061581 HSPA1B 2.76 0.039 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs5491 ICAM1 — 5e-66 5036 — American 28-70 TT, AT AA Genome-Wide Association Study 22174011
    rs2227956 HSPA1L — 0.01 191 vs 53 — Chinese >90 TC TT/CC Candidate Region/Gene 19840767
    rs2430561 IFNG — 0.02 174 vs 248 — Italian >99 T (females) — Candidate Region/Gene 11772518
    rs1059234 CDKN1A 0.47 0.026 184 vs 184 — Italian 100 T C Candidate Region/Gene 20126416
    rs1501299 ADIPQO — 0.02 110 vs 120 — Jordanian mean age 90.2 years T G Candidate Region/Gene 20201642
    rs1805081 NPC1 — 0.007 152 vs 120 — Polish >100 T C Candidate Region/Gene 18834923
    rs987839 SLCO1B1 — 3.19e-06 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs17811551 ADAMTS6 — 3.74e-06 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs12740413 ARHGEF19 — 1.3e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs6962026 PSCD3 — 2.07e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs11206814 — — 2.67e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs10485170 — — 3.67e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs10085518 PSCD3 — 4.59e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs6491207 — — 4.63e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs7952321 OR5AS1 — 4.68e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T G Genome-Wide Association Study 22445811
    rs662 PON1 — 0.04 1265 vs 582 541 total Danish 93 R Q Candidate Region/Gene 15241482
    rs1801282 PPARG 0.13 0.03 114 vs 173 — Italian >/=90 Pro/Ala Pro/Pro, Ala/Ala Candidate Region/Gene 22985084
    rs2234693 ESR1 — 0.08 108 vs 85 — Italian 90+ PP (genotype) — Candidate Region/Gene 20819792
    rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young — Italian 91+, 73-91 P — Candidate Region/Gene 23125046
    rs5882 CETP 3.56 0.001 213 vs 258 — Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
    rs978739 TAS2R16 0.62 0.001 348 vs 593 — Calabrian Mean age 93.82 non-AA AA Candidate Region/Gene 23133589
    rs1800624 — — 0.028 28 vs 56 — Caucasian 90+ non-AA AA Candidate Region/Gene 24284407
    mt146 C>T — — 0.005 113 (cases) vs 200 — Chinese 90-110 mt146T mt146C Complete Mitochondrial Genome 22729909
    • Page 1 of 23
    • 25 of 572 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue