Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

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    ‑ (19)   Candidate Region/Gene (382)   Meta‑Analysis (8)   Genome‑Wide Association Study (103)   Mitochondrial Haplogroup (27)  
  • Variant type: + -
    SNP (314)   Haplotype (43)   Other (1)   STR (7)   Deletion (1)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs5742612 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
    rs35767 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
    rs17630266 FOXO1 — 1.0 761 vs 1056 350 vs 350 Chinese mean age 102.3 — — Candidate Region/Gene 19793722
    rs2866164 MTTP — 1.0 1651 vs 575 — Danish 92-93 — — Candidate Region/Gene 16015282
    length (STR polymorphism) TH — 1.0 196 vs 358 471 vs 462 German (in replication) 96-110 years — — Candidate Region/Gene 21407269
    rs9340799 ESR1 — 1.0 148 vs 414 — Polish mean age 101.1 — — Candidate Region/Gene 20599431
    CTSD CTSD — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    AGT AGT — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    TP53 TP53 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    DRD4 DRD4 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    SLC6A4 SLC6A4 — 1.0 224 vs 441 — Ashkenazi Jewish 75 — — Candidate Region/Gene 15621215
    rs72533289 KIR2DS4 — 1.0 180 vs 180 — Irish Mean age 89 — — Candidate Region/Gene 15130674
    rs1800629 TNF — 1.0 174 vs 224 — Italian >100 — — Candidate Region/Gene 12676903
    rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
    rs5182 AGTR1 0.97 1.0 173 vs 376 — Italian 99-106 (mean 100.9±1.7) — — Candidate Region/Gene 22569962
    rs5183 AGTR1 0.27 1.0 173 vs 376 — Italian 99-106 (mean 100.9±1.7) — — Candidate Region/Gene 22569962
    rs1799814 CYP1A1 1.16 1.0 205 vs 294 — German 80-89; reference group: 17-79 — — - 15177664
    - PARP1 — 1.0 239 vs 198 — French >100 — — Candidate Region/Gene 9587069
    rs2153960 FOXO3A — 1.0 1435 vs 2098 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs7762395 FOXO3A — 1.0 2832 vs 2168 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs13220810 FOXO3A — 1.0 1746 vs 1219 — Multiethnic 90+ — — Meta-Analysis 25038186
    rs7843014 PTK2 — 1.0 79 vs 316 — Italian 100-104 — — Candidate Region/Gene 24930376
    rs7460 PTK2 — 1.0 79 vs 316 — Italian 100-104 — — Candidate Region/Gene 24930376
    rs7843014 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376
    rs7460 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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