Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (243)   No Age Effect (314)  
  • Study type: + -
    GWAS (2)   ‑ (1)   Candidate Region/Gene (375)   Meta‑Analysis (37)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (147)   Mitochondrial Haplogroup (1)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP « 
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs876581 CDKN1A 0.58 0.103 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs870959 — 1.51 2.84e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs861539 XRCC3 — 0.97 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
    rs846427 — 1.94 3.82e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs8192678 PPARGC1A — 0.469 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs8192291 SOD3 — 0.144 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    rs8192290 SOD3 — 0.428 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    rs8192287 SOD3 — 0.955 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    rs81647 — 0.58 9.77e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs8052394 MT1a 2.16 0.0002 151 vs 100 — Italian Mean age 91.4 +/- 4.1 — A Candidate Region/Gene 16955215
    rs8031 SOD2 — 0.186 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    rs800140 TSPAN32 — 0.0081 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs7981045 FOXO1 1.06 0.349 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs795602 MGST2 0.67 4.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs7915479 CDH23 1.92 2.81e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs7914 CBL — 0.69 190 vs 376 — Japanese 95+ — — Candidate Region/Gene 23770741
    rs7873259 ANKRD19 3.14 1.18e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs7855 SOD2 — 0.842 1612 vs 1104 — German 90+ — — Candidate Region/Gene 24163049
    rs7843014 — 0.37 0.001 175 vs 355 — Spanish 100-111 A C Candidate Region/Gene 24930376
    rs7843014 PTK2 — 1.0 79 vs 316 — Italian 100-104 — — Candidate Region/Gene 24930376
    rs7843014 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376
    rs7842001 — 0.32 7.12e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs7799039 LEP — 0.02 110 vs 120 — Jordanian mean age 90.2 years C A Candidate Region/Gene 20201642
    rs7799039 LEP — 0.048 128 vs 414 — Polish 100+ — GG Candidate Region/Gene 24549597
    rs7762395 FOXO3 1.38 0.005 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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