Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (243)   No Age Effect (314)  
  • Study type: + -
    GWAS (2)   ‑ (1)   Candidate Region/Gene (375)   Meta‑Analysis (37)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (147)   Mitochondrial Haplogroup (1)   Mitochondrial genome (3)  
  • Variant type: + -
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs9400239 FOXO3 1.38 0.0007 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs3800231 FOXO3 1.42 0.0002 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs1268170 FOXO3 1.24 0.02 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs473268 FOXO3 1.21 0.044 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs479744 FOXO3 1.40 0.001 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs519007 FOXO3 0.93 0.55 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs1800629 TNFa — 0.168 See Description for details — Italian Comparison 1: 66-91. Comparison 2: >88 — — Candidate Region/Gene 21865054
    rs361525 TNFa — 0.156 See Description for details — Italian Comparison 1: 66-91. Comparison 2: >88 — — Candidate Region/Gene 21865054
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A — Candidate Region/Gene 22406557
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    rs1008438 HSPA1A — 0.009 894 total — Italian 18-109 A C Candidate Region/Gene 16896546
    rs6457931 CDKN1A 1.01 0.936 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs1485780 CD2AP — 0.604 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
    rs3757354 MYLIP — 6.4e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
    rs6459623 IBRDC2 — 0.00015 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
    rs697739 ATXN1 0.59 8.97e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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