Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
    rs1800629 TNF — 0.019 747 — Italian 19-110 A G Candidate Region/Gene 18511747
    rs1800629 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
    rs1800629 TNF — 1.0 174 vs 224 — Italian >100 — — Candidate Region/Gene 12676903
    rs1800629 TNF — 0.76 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
    rs1800629 TNFa — 0.168 See Description for details — Italian Comparison 1: 66-91. Comparison 2: >88 — — Candidate Region/Gene 21865054
    rs1801270 CDKN1A 0.44 0.02 184 vs 184 — Italian 100 A C Candidate Region/Gene 20126416
    rs1935949 FOXO3A 1.46 0.019 299 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 114 T — Candidate Region/Gene 19489743
    rs2153960 FOXO3A 1.16 0.019 300 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 115 — — Candidate Region/Gene 19489743
    rs2227956 HSPA1L — 0.328 168 cases — Danish Mean age 92.8 +/- 0.4 — — Candidate Region/Gene 20388090
    rs2234693 ESR1 — 0.08 108 vs 85 — Italian 90+ PP (genotype) — Candidate Region/Gene 20819792
    rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    rs2242653 BAT5 1.39 0.000314783 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2253310 FOXO3 1.35 7.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C G Candidate Region/Gene 19793722
    rs2269475 AIF1 1.45 0.000435495 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2274776 FOXO3 0.95 0.536 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs2758331 SOD2 1.33 2.92563e-05 801 vs 914 — Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs2764264 FOXO3 — 0.0002 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs2764264 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs2802288 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs2802290 FOXO3 1.26 0.01 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
    rs2802292 FOXO3 1.36 2.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 G T Candidate Region/Gene 19793722
    rs2802292 FOXO3 — 0.0001 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs2802292 FOXO3 1.34 0.0078 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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