Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1800629 TNF — 0.019 747 — Italian 19-110 A G Candidate Region/Gene 18511747
    HFE C282Y HFE — 7.2e-07 35 vs 106 — 91-105 (< 50 versus >90) C Y Candidate Region/Gene 11857056
    rs1799945 HFE — 0.008 57 vs 60 — Italian 100-105 — — Candidate Region/Gene 12714263
    rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    Ile119Val PCMT1 — 0.049 40 vs 40 — Ashkenazi Jewish Mean age 87.2 — — Candidate Region/Gene 10496068
    HLA-DRB1 haplotypes HLA-DRB1 — 0.004 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-DRB1*0401 alleles DRB1*0401 Candidate Region/Gene 9389323
    HLA-DQB1 haplotypes HLA-DQB1 — 0.0002 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-DQB1*0503 alleles DQB1*0503 Candidate Region/Gene 9389323
    HLA-DQA1 haplotypes HLA-DQA1 — 0.04 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-HLA-DQA1*0101=0104 alleles HLA-DQA1*0101=0104 Candidate Region/Gene 9389323
    HLA-DQA1 haplotypes HLA-DQA1 — 0.038 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-HLA-DQA1*05 alleles HLA-DQA1*05 Candidate Region/Gene 9389323
    TNF haplotypes TNF — 0.01 60 vs 50 — Bulgarian Age range: 65-99 — −1031 C/C, −863 C/A, −857 C/C, −308 G/G, +489 G/G Candidate Region/Gene 21299522
    HLA DRB1*18 HLA-DRB1 — 0.0266 77 vs 299 — 100 — — Candidate Region/Gene 20426625
    rs1008438 HSPA1A — 0.005 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1061581 HSPA1L — 0.04 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    rs9340799 ESR1 — 0.22 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    DR7 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
    DR11 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
    DR13 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
    rs2764264 FOXO3 — 0.0002 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs13217795 FOXO3 — 0.0006 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs2802292 FOXO3 — 0.0001 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
    rs282070 MAP3K7 — 0.0011 288 vs 554 — Calabrian 90+, median 92 G — Candidate Region/Gene 22576335
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    rs3800358 BTBD9 — 0.00541 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs1008438 HSPA1A — 0.009 894 total — Italian 18-109 A C Candidate Region/Gene 16896546
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    • 25 of 84 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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