Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs5746098 SOD2 — 0.355 130 vs 135 — Jordanian Mean age 90.01 — — Candidate Region/Gene 20003469
    rs3757354 MYLIP — 6.4e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
    rs6459623 IBRDC2 — 0.00015 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
    rs1485780 CD2AP — 0.604 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs9340799 ESR1 — 1.0 148 vs 414 — Polish mean age 101.1 — — Candidate Region/Gene 20599431
    -351A/G ESR1 — 0.05 148 vs 414 — Polish 99.6-107.2; mean= 101.1±1.2 — — Candidate Region/Gene 20599431
    -397T/C ESR1 — 0.06 149 vs 414 — Polish 99.6-107.2; mean= 101.1±1.3 — — Candidate Region/Gene 20599431
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.72 0.01 152 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR7 alleles DR7 Candidate Region/Gene 9425225
    ?60H LMP2 — 0.756 157 vs 311 — Italian 88+ H — Candidate Region/Gene 11772516
    ?145K LMP7 — 0.849 157 vs 311 — Italian 88+ K — Candidate Region/Gene 11772516
    rs1008438 HSPA1A — 0.005 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1061581 HSPA1B — 0.04 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1008438 HSPA1A — 0.005 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1061581 HSPA1L — 0.04 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs4880 SOD2 0.91 0.002 1650 — Danish All danes born in 1905 (Danish 1905 cohort) T — Candidate Region/Gene 19428448
    rs699947 VEGFA 1.43 0.008 166 vs 324 — Italian 85-99 (mean 89.8±2.8) C A Candidate Region/Gene 17574707
    −1190G/A VEGFA 1.39 0.014 166 vs 324 — Italian 85-99 (mean 89.8±2.8) G A Candidate Region/Gene 17574707
    rs1008438 HSPA1A 3.86 0.016 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs1061581 HSPA1B 2.76 0.039 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs2227956 HSPA1L — 0.328 168 cases — Danish Mean age 92.8 +/- 0.4 — — Candidate Region/Gene 20388090
    rs1800629 TNF — 1.0 174 vs 224 — Italian >100 — — Candidate Region/Gene 12676903
    rs1801270 CDKN1A 0.44 0.02 184 vs 184 — Italian 100 A C Candidate Region/Gene 20126416
    rs1059234 CDKN1A 0.47 0.026 184 vs 184 — Italian 100 T C Candidate Region/Gene 20126416
    rs6457931 CDKN1A 1.01 0.936 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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