Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs361525 TNFa — 0.156 See Description for details — Italian Comparison 1: 66-91. Comparison 2: >88 — — Candidate Region/Gene 21865054
    rs1800629 TNFa — 0.168 See Description for details — Italian Comparison 1: 66-91. Comparison 2: >88 — — Candidate Region/Gene 21865054
    rs479744 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 (can't figure out using ensemble and NCBI) — Candidate Region/Gene 20849522
    rs3800231 FOXO3 1.26 0.0495 1089 vs 736 — Danish 92–93 G — Candidate Region/Gene 20849522
    rs9398172 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 A — Candidate Region/Gene 20849522
    rs9400239 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs13217795 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs7762395 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 G — Candidate Region/Gene 20849522
    rs2764264 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs13220810 FOXO3 0.75 0.0223 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs2802292 FOXO3 1.34 0.0078 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs12206094 FOXO3 1.38 0.0076 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs9486902 FOXO3 1.40 0.0118 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs648802 PERP 1.29 0.012 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C — Candidate Region/Gene 20800603
    -397T/C ESR1 — 0.06 149 vs 414 — Polish 99.6-107.2; mean= 101.1±1.3 — — Candidate Region/Gene 20599431
    -351A/G ESR1 — 0.05 148 vs 414 — Polish 99.6-107.2; mean= 101.1±1.2 — — Candidate Region/Gene 20599431
    rs9486913 FOXO3A 1.18 0.053 304 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 119 — — Candidate Region/Gene 19489743
    rs9486902 FOXO3A 1.18 0.073 303 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 118 — — Candidate Region/Gene 19489743
    rs4946935 FOXO3A 1.48 0.018 302 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 117 A — Candidate Region/Gene 19489743
    rs3778588 FOXO3A 1.22 0.023 301 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 116 — — Candidate Region/Gene 19489743
    rs2153960 FOXO3A 1.16 0.019 300 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 115 — — Candidate Region/Gene 19489743
    rs1935949 FOXO3A 1.46 0.019 299 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 114 T — Candidate Region/Gene 19489743
    rs1044891 FOXO3A 1.17 0.14 298 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 113 — — Candidate Region/Gene 19489743
    rs4880 SOD2 0.91 0.002 1650 — Danish All danes born in 1905 (Danish 1905 cohort) T — Candidate Region/Gene 19428448
    rs519007 FOXO3 0.93 0.55 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue