Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs9486902 FOXO3A 1.18 0.073 303 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 118 — — Candidate Region/Gene 19489743
    rs12200646 FOXO3 1.28 0.064 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    -397T/C ESR1 — 0.06 149 vs 414 — Polish 99.6-107.2; mean= 101.1±1.3 — — Candidate Region/Gene 20599431
    rs9486913 FOXO3A 1.18 0.053 304 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 119 — — Candidate Region/Gene 19489743
    LPA isoform LPA — 0.05 84 (cases) vs 517 — Japanese 80+ Lp(a)F, Lp(a)B — Candidate Region/Gene 11269751
    -351A/G ESR1 — 0.05 148 vs 414 — Polish 99.6-107.2; mean= 101.1±1.2 — — Candidate Region/Gene 20599431
    rs2764264 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs7762395 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 G — Candidate Region/Gene 20849522
    rs13217795 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs9400239 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs9398172 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 A — Candidate Region/Gene 20849522
    rs479744 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 (can't figure out using ensemble and NCBI) — Candidate Region/Gene 20849522
    C4B1 C4B — 0.05 77 (cases) vs 235 — Italian Mean age 101 — — Candidate Region/Gene 10219002
    rs3800231 FOXO3 1.26 0.0495 1089 vs 736 — Danish 92–93 G — Candidate Region/Gene 20849522
    Ile119Val PCMT1 — 0.049 40 vs 40 — Ashkenazi Jewish Mean age 87.2 — — Candidate Region/Gene 10496068
    rs473268 FOXO3 1.21 0.044 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs1061581 HSPA1B — 0.04 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    HLA-DQA1 haplotypes HLA-DQA1 — 0.04 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-HLA-DQA1*0101=0104 alleles HLA-DQA1*0101=0104 Candidate Region/Gene 9389323
    rs1061581 HSPA1L — 0.04 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1061581 HSPA1B 2.76 0.039 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    HLA-DQA1 haplotypes HLA-DQA1 — 0.038 120 vs 129 — Okinawan Mean age 102.3 +/- 1.9 years non-HLA-DQA1*05 alleles HLA-DQA1*05 Candidate Region/Gene 9389323
    HLA DRB1*18 HLA-DRB1 — 0.0266 77 vs 299 — 100 — — Candidate Region/Gene 20426625
    rs1059234 CDKN1A 0.47 0.026 184 vs 184 — Italian 100 T C Candidate Region/Gene 20126416
    rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
    rs3778588 FOXO3A 1.22 0.023 301 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 116 — — Candidate Region/Gene 19489743

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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