Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    −1190G/A VEGFA 1.39 0.014 166 vs 324 — Italian 85-99 (mean 89.8±2.8) G A Candidate Region/Gene 17574707
    TNF haplotypes TNF — 0.01 60 vs 50 — Bulgarian Age range: 65-99 — −1031 C/C, −863 C/A, −857 C/C, −308 G/G, +489 G/G Candidate Region/Gene 21299522
    rs9486902 FOXO3 1.40 0.0118 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A — Candidate Region/Gene 22406557
    rs9400239 FOXO3 1.38 0.0007 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs9397084 SYNE1 1.40 0.000104307 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs9340799 ESR1 — 0.22 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    rs7762395 FOXO3 1.38 0.005 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs768023 FOXO3 1.27 0.007 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs699947 VEGFA 1.43 0.008 166 vs 324 — Italian 85-99 (mean 89.8±2.8) C A Candidate Region/Gene 17574707
    rs6911407 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs648802 PERP 1.29 0.012 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C — Candidate Region/Gene 20800603
    rs524533 NFKBIE 1.29 0.000732713 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs519007 FOXO3 0.93 0.55 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs4946936 FOXO3 1.40 1.8e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 T C Candidate Region/Gene 19793722
    rs4946935 FOXO3A 1.48 0.018 302 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 117 A — Candidate Region/Gene 19489743
    rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    rs4880 SOD2 0.91 0.002 1650 — Danish All danes born in 1905 (Danish 1905 cohort) T — Candidate Region/Gene 19428448
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    rs479744 FOXO3 1.40 0.001 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs473268 FOXO3 1.21 0.044 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs3804474 FLJ33708 1.22 0.000264519 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs3800358 BTBD9 — 0.00541 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs3800231 FOXO3 1.42 0.0002 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
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    • 25 of 84 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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