Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
    rs5746098 SOD2 — 0.355 130 vs 135 — Jordanian Mean age 90.01 — — Candidate Region/Gene 20003469
    2437 T>C HSPA1L — 0.01 129 vs 100 — Irish 80–97 2437C — Candidate Region/Gene 12742533
    rs1800629 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
    rs909253 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
    rs1485780 CD2AP — 0.604 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs1008438 HSPA1A — 0.005 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1061581 HSPA1B — 0.04 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs1008438 HSPA1A — 0.005 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1061581 HSPA1L — 0.04 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1008438 HSPA1A 3.86 0.016 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs1061581 HSPA1B 2.76 0.039 168 cases — Danish Mean age 92.8 +/- 0.4 А — Candidate Region/Gene 20388090
    rs2227956 HSPA1L — 0.328 168 cases — Danish Mean age 92.8 +/- 0.4 — — Candidate Region/Gene 20388090
    rs4880 SOD2 0.91 0.002 1650 — Danish All danes born in 1905 (Danish 1905 cohort) T — Candidate Region/Gene 19428448
    rs9486902 FOXO3 1.40 0.0118 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs12206094 FOXO3 1.38 0.0076 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs2802292 FOXO3 1.34 0.0078 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs13220810 FOXO3 0.75 0.0223 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs2764264 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs7762395 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 G — Candidate Region/Gene 20849522
    rs13217795 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 T — Candidate Region/Gene 20849522
    rs9400239 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs9398172 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 A — Candidate Region/Gene 20849522
    rs3800231 FOXO3 1.26 0.0495 1089 vs 736 — Danish 92–93 G — Candidate Region/Gene 20849522

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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