Denigma

Interventions

  • Species: + -
    Fruit fly « 
  • Manipulation: + -
    Knockdown «  Loss‑of‑Function (26)   RNA Interference (20)   Mutation (1)   Transposition (1)  
    • name effect species mean median maximum
    Sir2 RNAi Decreased expression of Sir2 and Sir2-like genes in all cells causes lethality during development. Suppression of the Sir2 in neurons decreases the median lifespan by 10-30%, while ubiquitous silencing of the Sir2-like genes shortens lifespan. The effects are server at 28°C that at 25°C [17159295]. Fly — -10 to -30 —
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    • 1 of 26 interventions
    Interventions are an extension of GenAge and GenDR.