| RPS6A deletion | Deletion of RPS6A increases replicative lifespan by 30% in alpha strain [18423200; 18340043]. | Yeast | +30 | — | — |
| RPS27B deletion | Deletion of RPS27B decreases mean replicative lifespan decreased by 20 - 30% in the alpha strain [18423200; 19030232] and by 27% in the ORF collection as well as by 14% in the remade strain [22377630]. | Yeast | -14 to -30 | — | — |
| RPO41 mutation | RPO41 mutants exhibit reduced chronological lifespan accompanied by imbalanced mitochondrial translation, conditional inactivation of respiration, elevated production of reactive oxygen species, and increased oxidative stress [16782871]. | Yeast | — | — | — |
| RPL9B deletion | Deletion of RPL9B increases replicative lifespan by 30% in a strain [18423200; 18340043]. | Yeast | +30 | — | — |
| RPL9A deletion | Deletion of RPL9A increases replicative lifespan by 30% in the alpha strain and 20% in a strain [18423200; 18340043]. | Yeast | +20 to +30 | — | — |
| RPL4A deletion | Deletion of RPL4A increases replicative lifespan by 15% in the alpha strain [18340043]. RPL4A deletion increases replicative lifespan by 20% in the alpha strain [18423200]. | Yeast | +15 to +20 | — | — |
| RPL37B deletion | Deletion of RPL37B increases replicative lifespan by 35% in the alpha strain [18423200]. RPL37B deletion increases replicative lifespan by 35% in the alpha strain and 30% in a strain [19030232]. | Yeast | +30 to +35 | — | — |
| RPL10 deletion | Heterozygosity for RPL10 deletion increases median replicative lifespan by 24% [17174052]. | Yeast | — | +24 | — |
| RAD50 deletion | RAD50 mutations result in a 70% reduced replicative lifespan [10207108]. | Yeast | -70 | — | — |
| NMD4 deletion | Deletion of NMD4 increases replicative lifespan [16293764]. NMD4 deletion results in replicative lifespan increase by 25% in the alpha strain and decrease by 20% in a strain [19030232]. | Yeast | -20 to +25 | — | — |
| NDI1 deletion | Deletion of NDI1 results in chronological lifespan extension [16436509]. | Yeast | — | — | — |
| MXR2 overexpression | Overexpression of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions, but under DR conditions extends replicative lifespan by 120% [15141092]. | Yeast | — | — | — |
| MXR2 deletion | Deletion of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions, but simulatonous deletion of MXR2 together with MXR1 dramatically reduces replicative lifespan by 63% [15141092]. | Yeast | — | — | — |
| MXR1 overexpression | Overexpression of MXR1 (alias MsrA) slightly increases the replicative lifespan [15141092].
| Yeast | — | — | — |
| Methionine restriction | Restriction of the methionine content in the culture extends mean and maximum lifespan by up to 29 and 16% (1/10 methionine content) [15141092]. | Yeast | +29 | — | +16 |
| MXR1 deletion | Deletion of MXR1 (alias MsrA) decreases (by 25%) the replicative lifespan [15141092]. Deletion of MXR1 decreases replicative lifespan [19049972]. MXR1 deletion decreases replicative lifespan on either glucose or lactate as carbon source [20799725]. Although deletion or overexpression of MXR2 (alias MsrB) has no effect under normal growth conditions, the simultaneous deletion of MXR1 and MXR2 reduces the lifespan by 63% [15141092]. | Yeast | -25 | — | — |
| MRL4 deletion | MRS4 deletion decreases mean replicative lifespan by 30% in the alpha strain and 40% in a strain [18340043; 19030232]. | Yeast | -30 to -40 | — | — |
| MEP3 deletion | Deletion of MEP3 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| MEP2 deletion | Deletion of MEP2 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| MEC1 deletion | MEC1 mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion [17710147]. | Yeast | — | — | — |
| LYS9 deletion | Deletion of LYS9 increases replicative lifespan [16293764]. LYS9 deletion increases replicative lifespan by 20% in the alpha strain [19030232]. | Yeast | +20 | — | — |
| LIN1 deletion | Deletion of LIN1 increases replicative lifespan [16293764]. LIN1 deletion increases replicative lifespan by 40% in the alpha strain [19030232]. | Yeast | +40 | — | — |
| KSS1 deletion | Deletion of KSS1 results in increased sensitivity to heat shock and oxidative stress and a 25% reduction in median chronological lifespan [17662940]. | Yeast | — | -25 | — |
| MAPK1 overexpression | Overexpression of human MAPK1 (alias ERK2) confers resistance to heat shock and oxidative stress extends median chronological lifespan by 24% and was statistically non-addative with cyr1-1 mutation [17662940]. | Yeast | — | +24 | — |
| TEC1 mutation | TEC(AxY) mutation reduces chronological lifespan, although not so pronounced as strains lacking TEC1. Rapamycin-induced chronological lifespan extension is almost completely blocked by TEC(AxY) allele [21840851]. | Yeast | — | — | — |
GenAge
GenDR
