| Overexpression of constitutive nuclear DAF-16 | Overexpression of constitutive nuclear forms of DAF-16 increases lifespan only slightly [11381260]. | Worm | — | — | — |
| clk-1 overexpression | Overexpression of clk-1 shortens lifespan and is associated with increased mitochondrial activity [10202142]. | Worm | — | — | — |
| aak-2 overexpression | Transgenic animals with a higher aak-2 gene dose live on average 13% longer with a maximum lifespan extension on up to 25% [15574588]. | Worm | +13 | — | +25 |
| tdp-1 overexpression | tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012]. | Worm | — | — | — |
| Coq7 overexpression | Transgenic overexpression of mouse Coq7 reverts the extended lifespan of clk-1 mutants [11511092]. | Worm | — | — | — |
| abu-11 overexpression | Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736]. | Worm | +9 to +28 | — | — |
| cst-1 overexpression | Overexpression of cst-1 extends lifespan and delays aging in a daf-16-dependent manner [16751106]. | Worm | — | — | — |
| SIR-2.4 overexpression | Overexpression of SIR-2.4 does not change the mean or maximum lifespan of wild-type nor the ncreased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. | Worm | — | — | — |
| jnk-1 overexpression | Overexpression of jnk-1 increases lifespan by 40% [15767565; 23097426].
JNK-1 overexpression extends the lifespan in a daf-16-dependent manner. JNK-1 overexpression does not extend the lifespan of animals unable to synthesize miRNAs, i.e. pash-1(mj100) [23097426]. | Worm | +40 | — | — |
| lin-4 overexpression | Overexpressing lin-4 extends lifespan [16373574]. | Worm | — | — | — |
| mir-71 overexpression | Gain-of-function of mir-71 increases lifespan [21129974]. Extra copies of mir-71 extend the lifespan with an increase in lifespan by 15 - 25% [22482727], | Worm | +15 to +25 | — | — |
| mir-246 overexpression | mir-246 overexpression increases mean and maximum lifespan by 6 and 5 - 14%, respectively [21129974]. | Worm | +6.3 | — | +4.8 to +14.3 |
| mir-239 overexpression | Overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. | Worm | -13 | — | -17 to -33 |
| nhr-62 Overexpression | Wild-type (N2) worms with extrachromosomal array dhEx627 (carrying a wild-type nhr-62) exhibit a significant increase in lifespan compared to wild-type (p<0.001) [Heestand et al. 2013]. | Worm | — | — | — |
| wwp-1 overexpression | wwp-1 overexpression extends lifespan by up to 20%. RNAi reduction of pha-4, but not of daf-16 suppresses increased longevity by wwp-1 overexpression [19553937]. | Worm | — | +20 | — |
| sod1 overexpression | Overexpression of sod1 increases mean, median, and maximum lifespan by 21, 25, and 29% [22737090]. | Worm | +23 | +25 | +44 |
| sod-1 overexpression | sod-1 overexpression increases mean, median, and maximum lifespan by 32, 25, and 35% [22737090]. | Worm | +32 | +25 | +35 |
| lyz overexpression | Overexpression of lyz increases mean, median, and maximum lifespan by 26, 30 and 44% [22737090]. | Worm | +26 | +30 | +44 |
| lmp-2 overexpression | Overexpression of lmp-2 increases mean, median and, maximum lifespan by 32, 35, and 41% [22737090]. | Worm | +32 | +35 | +41 |
| hsf-1 overexpression | Overexpression of hsf-1 extends the mean, median, and maximum lifespan by 37, 35, and 29% [22737090]. | Worm | +37 | +35 | +29 |
| ucp2 overexpression | Overexpression of ucp2 increases mean, median, and maximum lifespan by 42, 40, and 26%, which is non-additive with sDR [22737090]. | Worm | +42 | +40 | +26 |
| aakg-2 overexpression | Overexpression of aakg-2 extends mean, median, and maximum lifespan by 47, 45, and 35% [22737090]. | Worm | +47 | +45 | +35 |
GenAge
GenDR
