| mboa-1 RNAi | RNA interference of mboa-1 decreases median lifespan by 16% in wild type animals, 28% in a daf-2 background and 12% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -16 | — |
| C14A4.9 RNAi | RNA interference of C14A4.9 decreases median lifespan by 14% in wild type animals and 41% in daf-2 mutants [18006689]. | Worm | — | -14 | — |
| C26B0.3 RNAi | RNA interference of C26B0.3 decreases median lifespan by 12% in wild type animals, 68% in a daf-2 background and 17% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -12 | — |
| C29F9.2 RNAi | RNA interference of C29F9.2 decreases median lifespan by 12% in wild type animals and 36% in daf-2 mutants [18006689]. | Worm | — | -12 | — |
| cua-1 RNAi | RNA interference of cua-1 decreases median lifespan by 12% in wild type animals and 30% in daf-2 mutants. | Worm | — | -12 | — |
| Sir2 RNAi | Decreased expression of Sir2 and Sir2-like genes in all cells causes lethality during development. Suppression of the Sir2 in neurons decreases the median lifespan by 10-30%, while ubiquitous silencing of the Sir2-like genes shortens lifespan. The effects are server at 28°C that at 25°C [17159295]. | Fly | — | -10 to -30 | — |
| mdh-1 RNAi | RNAi against mdh-1 decreases median lifespan by 10% in wild type animals and by 16% in daf-2 mutants. mdh-1 RNAi started after the animal reached the late L4 stage increases mean and maximum lifespan by 4-27% and 9% [22103665]. | Worm | +4 to +27 | -10 | +9 |
| ain-1 RNAi | RNA interference of ain-1 decreases median lifespan by 10% in wild type animals, 20% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -10 | — |
| C11H1.3 RNAi | RNA interference of C11H1.3 decreases median lifespan by 10% in wild type animals, 14% in a daf-2 background and 41% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -10 | — |
| elo-2 RNAi | elo-1 RNAi in the adulthood extends lifespan by 8% [21386131]. | Worm | — | +8 | — |
| rnf-5 RNAi | RNAi of rnf-5 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| ubh-4 RNAi | RNAi of ubh-4 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| C18E9.4 RNAi | RNAi of C18E9.4 starting at L1 results in mean and median lifespan extension by about 4 and 8% [15998808]. | Worm | +4 | +8 | — |
| inx-14 RNAi | RNAi of inx-14 starting at L1 increases mean, 25%ile and median lifespan by 6, 8 and 14% [15998808]. | Worm | +6 | +8 | — |
| F35D2.3 RNAi | RNAi of F35D2.3 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| F40F8.5 RNAi | RNAi of F40F8.5 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| spt-4 RNAi | RNAi of spt-4 starting at L1 extends mean, 75%ile and median lifespan by 4, 8 and 8% [15998808]. | Worm | +4 | +8 | — |
| mecr-1 RNAi | RNAi of mecr-1 extends mean, median and 25%ile lifespan by 6, 8 and 8% [15998808]. | Worm | +6 | +8 | — |
| drr-1 RNAi | RNAi of drr-1 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. drr-1 RNAi significantly extends mean lifespan of wild-type by 37 - 44%, of daf-16 mutants by 18%, and of daf-2 mutants by 14%, but does not extend significantly the lifespan of eat-2 mutants. drr-1 RNAi does not affect pumping, but similar to DR reduces and delays reproduction as well as causes a slender appearance. drr-1 mRNA is 2-fold downregulated in response to DR [16103914]. | Worm | +3 to +44 | +8 | — |
| crtc-1 RNAi | RNAi of crtc-1 extended median lifespan by up to 53% [21331044]. | Worm | — | +53 | — |
| vps-37 RNAi | RNA interference of vps-37 decreases median lifespan by 44% in wild-type animals, 47% in a daf-2 background and 33% in daf-2/daf-16 double mutants [18006689]. | Worm | — | +44 | — |
| eif-1 RNAi | RNA interference against eif-1 in the adulthood extends mean lifespan by 25% [17411345]. eif-1 RNAi only during the adulthood increases mean, median and 75th %ile lifespan by 23-35, 38 and 22-40%, respectively [22560223]. | Worm | +23 to +35 | +38 | — |
| ifg-1 RNAi | RNA interference against ifg-1 in the adulthood results in a 55% mean lifespan extension [17411345]. ifg-1 RNAi only in the adulthood increases mean, median and 75th %ile lifespan by 49, 33, and 35%, respectively [22560223]. RNAi knockdown of ifg-1 continuously at 25.5 degree Celsius extends mean and maximum lifespan by 31 and 11%, while knockdown restricted to the adulthood extends mean and maximum lifespan by 45 and 28% [16720740]. | Worm | +31 to +55 | +33 | +11 to +28 |
| raga-1 RNAi | raga-1 RNAi only during adulthood increases mean, median, 75th %ile and maximum lifespan by 9-42, 26-28, 16-52 and 35%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Lifespan of the skn-1;daf-16 mutant was unaffected by raga-1 RNAi. Knockdown of raga-1 dramatically increases stress tolerance in an skn-1 but not daf-16-dependent manner [22560223]. | Worm | +9 to +42 | +26 to +28 | +35 |
| rheb-1 RNAi | rheb-1 RNAi extends lifespan by mimicking the DR effect. Under AL condition, rheb-1 RNAi extends lifespan by 19.1% and the longevity-promoting effects of two DR regimens sDR and intermittent fasting are abolished [19079239]. Knockdown of rheb-1 by RNAi only during the adulthood increases mean, median and 75th %ile lifespan by 18-25, 25 and 23-24%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Knockdown of rheb-1 dramatically enhances stress tolerance in an skn-1, but not daf-16-dependent manner [22560223]. | Worm | +18 to +25 | +25 | — |
GenAge
GenDR
