| fat-4 RNAi | fat-4 RNAi in the adulthood extends lifespan by 25% [21386131]. | Worm | — | 25 | — |
| fat-3 RNAi | fat-3 RNAi in the adulthood extends lifespan by 10-15% [19301819]. | Worm | — | 10-15 | — |
| cel-1 RNAi | RNA interference of cel-1 decreases median lifespan 76% in daf-2 mutants, 15% in daf-2/daf-16 double mutants, and 59% wild-type animals [18006689]. | Worm | — | -76 | — |
| arx-4 RNAi | RNA interference of arx-4 decreases median lifespan by 61% in a daf-2 background and 51% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -61 | — |
| Bub1b mutation | Bub1b mutation decreases median lifespan by 60% (from 15 to 6 months). Bub1b mutant mice develop many phenotypes suggestive of accelerated aging, including: progressive bilateral cataracts, substantial loss of sub dermal adipose tissue, spinal kyphosis, muscle atrophy, and decreased wound healing. Moreover, there is a pronounced increase in senescent associated Beta-galactosidase expression in late generation Bub1b mutant mice, indicative of increased rate of cellular senscence. Homozyogous knockout of Bub1b results in lethality, while heterozygous animals exhibit no aging phenotypes [15208629]. | Mouse | — | -60 | — |
| tag-249 RNAi | RNA interference of tag-249 decreases median lifespan by 58% in wild-type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -58 | — |
| bus-8 RNAi | RNA interference of bus-8 decreases median lifespan by 58% in wild-type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -58 | — |
| C33H5.18 RNAi | RNA interference of C33H5.18 decreases median lifespan by 44% in wild type animals, 77% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | — | — | -44 | — |
| vps-22 RNAi | RNA interference of vps-22 decreases median lifespan by 43% in wild type animals, 33% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -43 | — |
| C06A5.1 RNAi | RNA interference of C06A5.1 decreases median lifespan by 39% in wild type animals, 24% in a daf-2 background and 71% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -39 | — |
| cyp-42A1 RNAi | RNA interference of cyp-42A1 decreases median lifespan by 39% in wild type animals, 77% in a daf-2 background and 37% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -39 | — |
| hsf-1 RNAi | hsf-1 RNAi abrogates lifespan extension by daf-2(e1370) mutation, but not eat-2(ad1116) or isp-1(qm150). HSF-1, like DAF-16, is required for daf-2 mutations to extend lifespan [12750521]. RNA interference of hsf-1 suppresses normal dauer formation and life-extension due to insulin-like signaling [14668486]. hsf-1 RNAi also prevents lifespan extension by bDR. bDR significantly reduces paralysis of Q35YFP or ABeta42 transgenic animals and hsf-1 RNAi totally cancels this effect. hsf-1 RNAi attenuates lifespan extension by bDR, but only partially that of daf-2 mutation. hsf-1 RNAi attenuates protection against oxidative stress by bDR. hsf-1 expression is induced by bDR [19924292]. RNAi of hsf-1 shortens median and maximum lifespan by approximately 35%. hsf-1 RNAi animals exhibit phenotypes associated with accelerated aging (as assyed by Nomarsky microscopy) [12136014]. | Worm | — | -35 | -35 |
| arl-8 RNAi | RNA interference of arl-8 decreases median lifespan by 35% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -35 | — |
| vps-33.1 RNAi | RNA interference of vps-33.1 decreased median lifespan 30% in daf-2 mutants and 15% in a wild-type background [18006689]. | Worm | — | -30 | — |
| agmo-1 RNAi | RNA interference of agmo-1 decreases median lifespan by 30% in wild type animals and 60% in daf-2 mutants [18006689]. | Worm | — | -30 | — |
| tbc-7 RNAi | RNA interference of tbc-7 decreased median lifespan by 28% in daf-2 mutants [18006689]. | Worm | — | -28 | — |
| C01F1.1 RNAi | RNA interference of C01F1.1 decreases median lifespan by 28% in wild-type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -27 | — |
| C07A9.2 RNAi | RNA interference of C07A9.2 decreases median lifespan by 26% in wild type animals, 37% in a daf-2 background and 15% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -27 | — |
| cit-1.2 RNAi | RNA interference cit-1.2 decreases median lifespan by 27% in daf-2 mutants [18006689]. | Worm | — | -27 | — |
| lin-40 RNAi | RNA interference decreases median lifespan by 24% in wild-type animals, 38% in a daf-2 background and 24% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -24 | — |
| sbds-1 RNAi | RNA interference of sbds-1 decreases median lifespan by 24% in daf-2 mutants [18006689]. | Worm | — | -24 | — |
| alg-2 RNAi | RNA interference of alg-2 decreases median lifespan by 24% in wild type animals and 50% in a daf-2 background [18006689]. | Worm | — | -24 | — |
| calu-1 RNAi | RNA interference of calu-1 decreases median lifespan by 23% in a daf-2 background and 15% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -23 | — |
| cdk-7 RNAi | RNA interference of cdk-7 decreases median lifespan by 18% in a daf-2 background and 19% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -18 | — |
| blmp-1 RNAi | RNA interference of blmp-1 decreases median lifespan by 17% in a daf-2 background and 20% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -17 | — |
GenAge
GenDR
