Interventions

  • name effect species mean median maximum
    fat-4 RNAi fat-4 RNAi in the adulthood extends lifespan by 25% [21386131]. Worm 25
    fat-3 RNAi fat-3 RNAi in the adulthood extends lifespan by 10-15% [19301819]. Worm 10-15
    wwp-1 mutation Loss of wwp-1 function by mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants [19553937]. Worm -9
    wwp-1 RNAi RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937]. Worm -9
    VMA2 deletion VMA2 deletion mutants have a reduced ΔΨ and mitochondrial morphology similar to aged cells. The restoration of the vacuolar acidity in daughter cells requires V-ATPase activity as it is eliminated in VMA2 deletion mutant cells [23172144]. VMA2 deletion mutation decreases the mean replicative lifespan by 80% in the alpha strain [18340043]. Deletion of VMA2 decreases mean, median and maximum replicative lifespan by 84%, 84% and 70%, respectively. DR (0.5% glucose restriction) does not extend the replicative lifespan of VMA2 and shortens it even more [23172144]. Yeast -80 to -83.9 -84.1 -70.0
    cel-1 RNAi RNA interference of cel-1 decreases median lifespan 76% in daf-2 mutants, 15% in daf-2/daf-16 double mutants, and 59% wild-type animals [18006689]. Worm -76
    arx-4 RNAi RNA interference of arx-4 decreases median lifespan by 61% in a daf-2 background and 51% in daf-2/daf-16 double mutants [18006689]. Worm -61
    Bub1b mutation Bub1b mutation decreases median lifespan by 60% (from 15 to 6 months). Bub1b mutant mice develop many phenotypes suggestive of accelerated aging, including: progressive bilateral cataracts, substantial loss of sub dermal adipose tissue, spinal kyphosis, muscle atrophy, and decreased wound healing. Moreover, there is a pronounced increase in senescent associated Beta-galactosidase expression in late generation Bub1b mutant mice, indicative of increased rate of cellular senscence. Homozyogous knockout of Bub1b results in lethality, while heterozygous animals exhibit no aging phenotypes [15208629]. Mouse -60
    tag-249 RNAi RNA interference of tag-249 decreases median lifespan by 58% in wild-type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants [18006689]. Worm -58
    bus-8 RNAi RNA interference of bus-8 decreases median lifespan by 58% in wild-type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants [18006689]. Worm -58
    C33H5.18 RNAi RNA interference of C33H5.18 decreases median lifespan by 44% in wild type animals, 77% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. -44
    vps-22 RNAi RNA interference of vps-22 decreases median lifespan by 43% in wild type animals, 33% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. Worm -43
    C06A5.1 RNAi RNA interference of C06A5.1 decreases median lifespan by 39% in wild type animals, 24% in a daf-2 background and 71% in daf-2/daf-16 double mutants [18006689]. Worm -39
    cyp-42A1 RNAi RNA interference of cyp-42A1 decreases median lifespan by 39% in wild type animals, 77% in a daf-2 background and 37% in daf-2/daf-16 double mutants [18006689]. Worm -39
    arl-8 RNAi RNA interference of arl-8 decreases median lifespan by 35% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. Worm -35
    hsf-1 RNAi hsf-1 RNAi abrogates lifespan extension by daf-2(e1370) mutation, but not eat-2(ad1116) or isp-1(qm150). HSF-1, like DAF-16, is required for daf-2 mutations to extend lifespan [12750521]. RNA interference of hsf-1 suppresses normal dauer formation and life-extension due to insulin-like signaling [14668486]. hsf-1 RNAi also prevents lifespan extension by bDR. bDR significantly reduces paralysis of Q35YFP or ABeta42 transgenic animals and hsf-1 RNAi totally cancels this effect. hsf-1 RNAi attenuates lifespan extension by bDR, but only partially that of daf-2 mutation. hsf-1 RNAi attenuates protection against oxidative stress by bDR. hsf-1 expression is induced by bDR [19924292]. RNAi of hsf-1 shortens median and maximum lifespan by approximately 35%. hsf-1 RNAi animals exhibit phenotypes associated with accelerated aging (as assyed by Nomarsky microscopy) [12136014]. Worm -35 -35
    Rbp9 mutation Rbp9 mutation significantly decreases longevity with a 33% reduction in median lifespan of males [20589912]. Fly -33
    agmo-1 RNAi RNA interference of agmo-1 decreases median lifespan by 30% in wild type animals and 60% in daf-2 mutants [18006689]. Worm -30
    vps-33.1 RNAi RNA interference of vps-33.1 decreased median lifespan 30% in daf-2 mutants and 15% in a wild-type background [18006689]. Worm -30
    tbc-7 RNAi RNA interference of tbc-7 decreased median lifespan by 28% in daf-2 mutants [18006689]. Worm -28
    C01F1.1 RNAi RNA interference of C01F1.1 decreases median lifespan by 28% in wild-type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. Worm -27
    C07A9.2 RNAi RNA interference of C07A9.2 decreases median lifespan by 26% in wild type animals, 37% in a daf-2 background and 15% in daf-2/daf-16 double mutants [18006689]. Worm -27
    cit-1.2 RNAi RNA interference cit-1.2 decreases median lifespan by 27% in daf-2 mutants [18006689]. Worm -27
    Terc deletion Telomerase null mice exhibit age-dependent telomere shortening and shortened lifespan with succeeding generations. Median lifespan is reduced by 26% in G6 Terc(-/-) mice compared to wild-type or G1-G3 Terc(-/-) (18 months vs. 24 months). G6 Tec(-/-) display hair greying, hair loss, and ulcerative skin lesions, as well as impaired response to wound healing and hematoitopitic ablation, and an increased incidence of cancer [10089885]. Cells from Terc(-/-) mice (G4 and upward) exhibit chromosomes lacking detectable teloemre repeats, aneuplody, and end-to-end fusions [9335332]. Mouse -26
    KSS1 deletion Deletion of KSS1 results in increased sensitivity to heat shock and oxidative stress and a 25% reduction in median chronological lifespan [17662940]. Yeast -25
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    • 25 of 1570 interventions
    Interventions are an extension of GenAge and GenDR.