| CG5389 RNAi | RNAi of complex V subunit CG5389 results in increased mean longevity under standard laboratory food conditions (3% yeast) in males. RNAi started from the development results in a mild lifespan increase in both sexes (3-11% in females and 3-8% in males). Post-developmental RNAi and silencing limited to neurons has variable effects with reduction in lifespan of up to 9% [19747824]. Under rich media conditions CG5389 knockdown throughout development and adulthood increases mean lifespan by 26% and abolished the lifespan extension by DR (started in the adulthood) in males. Suppression of CG5389 only during the adulthood either via RNAi by tub-GS or via oligomycin (a specific inhibitor of complex V) feeding prevents an increase in longevity under DR (started in the adulthood) in males [19968629]. | Fly | -9 to +26 | — | — |
| dor mutation | Loss-of-function mutation in dor reduces mean lifespan by 70 - 81% and maximum lifespan by 71 - 78% [17435236]. | Fly | -70 to -81 | — | -71 to -78 |
| SdhB mutation | SdhB mutants are hypersensitive to oxygen and displays signs of premature aging, including a 66% decrease in mean lifespan and a 17% decrease in maximum lifespan [17056719]. | Fly | -66 | — | -17 |
| hk mutation | Loss of function mutation in hk decreases mean lifespan by 58 - 60% and maximum lifespan by 15 - 47% [17435236]. | Fly | -58 to -60 | — | -15 to -47 |
| lt mutation | Loss-of-function mutation reduces mean lifespan by 47% and maximum lifespan by 10% [17435236]. | Fly | -47 | — | -10 |
| ry mutation | Loss-of-function mutation of ry reduces mean lifespan by 45% and maximum lifespan by 35% [17435236]. | Fly | -45 | — | -35 |
| cm mutation | Loss-of-function mutation in cm reduces mean lifespan by 43 - 53% and maximum lifespan by 40 - 44% [17435236]. | Fly | -43 to -53 | — | -40 to -44 |
| Hsp22 transposition | Animals that do not express Hsp22 (due to a transposition into its transcriptional starting site) have a 40% decrease in lifespan, exhibit a 30% decrease in locomotor activity and are sensitive to mild stress [20036725]. | Fly | -40 | — | — |
| car mutation | Loss-of-function mutation in car results in reduction of mean lifespan by 34 - 63% and maximum lifespan by 28 - 29% [17435236]. | Fly | -34 to -63 | — | -28 to -29 |
| car mutation | Loss-of-function mutation in car results in reduction of mean lifespan by 34 - 53% and maximum lifespan by 28 - 29% [17435236]. | Fly | -34 to -53 | — | -28 to -29 |
| pex16 mutation | pex16 mutation lead to a reduced mean lifespan of one-third in females and on-fourth in males. The short lifespan can be rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons [21826223].
Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects in the development of the nervous system [21826223]. | Fly | -33 to -75 | — | — |
| rb mutation | Loss-of-function mutation reduces mean lifespan by 33 and maximum lifespan by 22% [17435236]. | Fly | -33 | — | -22 |
| CG3776 underexpression | Underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher. The lifespan of females and male flies underexpressed CG3776 is reduced by 31.6% and 38.8%, respectively when compared with Oregon R flies [18275960]..
| Fly | -31.6 to -38.8 | — | — |
| Hk mutation | Genetic mutation in Hyperkinetic shortens lifespan through acceleration of the aging process. At 25 degree Celsius mean and maximum lifespan is reduced by 29 and 32%, while by 18 degree Celsius the reduction is 59 and 39% [8582611]. | Fly | -29 to -59 | — | -32 to -39 |
| bchs mutation | Loss of function mutation in bchs results in a 40-45% decrease in mean lifespan and is associated with age-related neurodegenerative phenotype with reduced CNS size and altered morphology as well as accumulation of insoluble ubiquinated proteins and amyloid precursor-like proteins along with an increase in neuronal apoptosis. No pronounced developmental defects were observed and young adults have normal behaviours, indicating that the bchs gene is essential for normal adult survival and longevity [12598614].
bchs mutation reduces mean lifespan by 28 - 54% and maximum lifespan by 24 - 46% [17435236]. | Fly | -28 to -54 | — | -24 to -46 |
| Aut1 RNAi | Aut1 depletion by RNAi form the first day of imaginal stage shortens lifespan by 28% on average in Drosophila and causes morphological behavioural features of premature aging [18219227]. | Fly | -28 | — | — |
| SNF4Agamma deletion | Deletion of SNF4Agamma from the first day of the imaginal stage shortens mean lifespan by 23% and causes morphological and behavioural features of premature aging [18219227]. | Fly | -23 | — | — |
| sdhC dominant negative overexpression | Mutants expressing a dominant negative form of sdhC in the nervous system have a 22% reduced mean lifespan and signs of oxidative stress induction [17854771]. | Fly | -22 | — | — |
| DLP mutation | DLP mutants have a 20% shorter mean lifespan and reduced female fertility [17933869]. | Fly | -20 | — | — |
| Sirt6 RNAi | Decreased expression of Sirt6 by RNA interference causes lethality during development. Sirt6 silencing in neurons shortens mean lifespan by 20% [17159295]. | Fly | -20 | — | — |
| Sirt2 RNAi | Decreased expression of Sirt2 by RNA interference causes lethality during development. Silencing in neurons shortened mean lifespan by 20% [17159295]. | Fly | -20 | — | — |
| Dcr-2 mutation | Median lifespan of homozyogous and transheterozyogous Dcr-2 mutants is reduced by 18-36% in males and by 27-36% in females. Dcr-2 loss changes the expression of mostly metabolic genes implicated in stress resistance and aging. Dcr-2 mutants are hypersensitive to oxidative, endoplasmic reticulum, starvation and cold stress as well as abnormal lipid and carbohydrate metabolism [21889502].
| Fly | -18 to -36 | — | — |
| Sh mutation | Genetic mutation in Sh decrease lifespan by accelerating the aging proces. At 25 degree mean and maximum lifespan is reduced by 16 and 22%, while by 18 degree Celsius the reduction is 32 and 21% [8582611]. | Fly | -16 to -32 | — | -21 to -22 |
| Akt1 RNAi | RNA interference of Akt1 in intestinal stem cells, results in impaired regeneration of the intestinal epithelium and a short lifespan. In males and females on mean lifespan is 11.4% and 7.4% lower [20976250]. | Fly | -11.4 to -7.4 | — | — |
| g mutation | Loss-of-function mutation reduces mean lifespan by 11 - 42% and maximum lifespan by 7 - 30% [17435236]. | Fly | -11 to -42 | — | -7 to -30 |
GenAge
GenDR
