| daf-16 RNAi | Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016].
RNAi against daf-16 decreases lifespan of wild-type, daf-2 or glp-1 mutants [22509016; 16530050]. daf-16 RNAi completely blocks lifespan extension by daf-2 mutation, but only partially by bDR. daf-16 RNAi attenuates protection against oxidative stress by bDR. Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016]. daf-16 RNAi decreases mean lifespan by 27% [18828672].
| Worm | -27 to 50 | — | -54 |
| nekl-2 RNAi | RNA intereference of nekl-2 decreases lifespan by 24% and suppresses lifespan extension by eat-2 mutation [22829775]. | Worm | -24 | — | — |
| dpy-27 RNAi | dpy-27 RNAi in the adulthood shortens mean and maximum lifespan by 24 and 25%, respectively [23144747]. | Worm | -23.5 | — | -25.0 |
| ncbp-2 RNAi | RNAi against ncbp-2 decreases mean and maximum lifespan by 23-25% and 7%, respectively [18059442]. | Worm | -23 to -25 | — | -7 |
| ctdl-7 RNAi | RNAi against cdtl-7 starting in the adulthood decreases the mean lifespan by 22.2% [New longevity regulators]. | Worm | -22.2 | — | — |
| cdtl-7 RNAi | RNAi against cdtl-7 starting in the adulthood decreases mean and maximum lifespan by 22 and 25%, respectively [23144747]. | Worm | -22.2 | — | -25.0 |
| rpt-2 RNAi | Knockdown of rpt-2 via RNAi started after the animal reached the late L4 stage decreases mean lifespan by 20-32% [22103665]. | Worm | -20 to -32 | — | — |
| sptf-3 RNAi | RNAi against sptf-3 decreases mean and maximum lifespan by 20 - 28% and 28%, respectively [18059442]. sptf-3 RNAi in the adulthood decreases the mean and maximum lifespan by 23 and 37% [23144747]. | Worm | -20 to -28 | — | -28 to -37 |
| amt-2 RNAi | RNA interference of amt-2 increases mean lifespan by 20% [17608836]. | Worm | -20 | — | — |
| Sirt6 RNAi | Decreased expression of Sirt6 by RNA interference causes lethality during development. Sirt6 silencing in neurons shortens mean lifespan by 20% [17159295]. | Fly | -20 | — | — |
| Sirt2 RNAi | Decreased expression of Sirt2 by RNA interference causes lethality during development. Silencing in neurons shortened mean lifespan by 20% [17159295]. | Fly | -20 | — | — |
| rpn-11 RNAi | rpn-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25%, respectively [23144747]. | Worm | -19.3 | — | -25.0 |
| Y47D3A.29 RNAi | RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. | Worm | -19-26 | — | -34 |
| pcf-11 RNAi | pcf-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25% [23144747]. | Worm | -18.9 | — | -25.0 |
| pas-1 RNAi | RNAi against pas-1 started after the animal reached the late L4 stage decreases mean lifespan by 18-19% [22103665]. RNAi pas-1 decreases lifespan of daf-2 mutant, but not of WT or glp-1 mutant [17392428]. | Worm | -18 to -19 | — | — |
| scl-20 RNAi | scl-20 appears to inhibit the growth of gld-1 tumours. RNA interference of scl-20 reduces mean lifespan up to 18% in wild-type animals, 15% in daf-2 mutants and 28% in daf-2/gld-1 mutants [17934462]. | Worm | -18 | — | — |
| tbp-1 RNAi | RNAi against tbp-1 decreases mean and maximum lifespan by 15-27% and 21%, respectively [18059442]. | Worm | -15-27 | — | -21 |
| eft-2 RNAi | Post-developmental RNA interference reduces mean lifespan by 15% [17673661]. Knockdown of eft-2 started after the animal reached the late L4 stage increases mean and maximum lifespan by 6-27% and 8%, respectively [22103665]. | Worm | -15 to +27 | — | +8 |
| bec-1 RNAi | bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. | Worm | -14 | — | -5 |
| Akt1 RNAi | RNA interference of Akt1 in intestinal stem cells, results in impaired regeneration of the intestinal epithelium and a short lifespan. In males and females on mean lifespan is 11.4% and 7.4% lower [20976250]. | Fly | -11.4 to -7.4 | — | — |
| bsk RNAi | RNA interference of bsk in intestinal stem cells, results in short lived mutants with impaired intestinal homeostasis and tissue regeneration. The mean lifespan of males is 16.4% lower and those of female is reduced by 10.2% [20976250]. | Fly | -10.2 to -16.4 | — | — |
| dct-11 RNAi | dct-11 stimulates the growth of gld-1 tumors. RNA interference of dct-11 increases mean lifespan up to 19% in a gld-1 mutant background and reduces mean lifespan by 10% in a wild-type background [17934462]. | Worm | -10 | — | — |
| ins-21 RNAi | RNA interference of ins-21 extends lifespan by 9%. ins-21 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. | Worm | +9% | — | — |
| raga-1 RNAi | raga-1 RNAi only during adulthood increases mean, median, 75th %ile and maximum lifespan by 9-42, 26-28, 16-52 and 35%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Lifespan of the skn-1;daf-16 mutant was unaffected by raga-1 RNAi. Knockdown of raga-1 dramatically increases stress tolerance in an skn-1 but not daf-16-dependent manner [22560223]. | Worm | +9 to +42 | +26 to +28 | +35 |
| rpl-7 RNAi | Kockdown of rpl-7 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 9-26% [22103665]. | Worm | +9 to +26 | — | — |
GenAge
GenDR
