| sos-1 RNAi | sos-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| SOD2 deletion | SOD2 deletion decreases replicative lifespan by 72% [17460215]. SOD2 deletion decreases chronological lifespan [21076178]. Deletion of SOD2 decreases chronological lifespan in wild-type and abolishes chronological lifespan extension in sch9Delta mutants as well as decreases chronological lifespan in cyr1:mTn mutants [12586694].
SOD2 deletion mutants are hypersensitive to oxygen and grow poorly in ethanol [10222047]. | Yeast | -72 | — | — |
| Sod1 knockdown | Sod1 knockdown by RNAi blunts the lifespan extension by a high sugar-low protein diet, but not a low-calorie diet [22672579]. | Fly | — | — | — |
| snr-5 RNAi | snr-5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| snap-1 RNAi | snap-1 RNAi in the adulthood reduces mean and maximum lifespan by 40 and 50%, respectively [23144747]. | Worm | -39.9 | — | -50.0 |
| slcf-1 RNAi | slcf-1 RNAi extends the lifespan [21040400]. | Worm | — | — | — |
| daf-28 mutation | Semi-dominant mutation in daf-28 increases lifespan by 10-15% [8807293]. The daf-28 mutant is dauer constitutive [8005442]. | — | +10 to +15 | — | — |
| scl-20 RNAi | scl-20 appears to inhibit the growth of gld-1 tumours. RNA interference of scl-20 reduces mean lifespan up to 18% in wild-type animals, 15% in daf-2 mutants and 28% in daf-2/gld-1 mutants [17934462]. | Worm | -18 | — | — |
| sbp-1 RNAi | sbp-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| sams-1 RNAi | sams-1 RNAi significantly extends lifespan of wild-type by 14 - 15%, of daf-16 mutant by 30% and daf-2 by 55%, but fails to significantly further extend lifespan of eat-2 mutants. mRNA level of sams-1 is 2-fold reduced in eat-2 mutants. Like DR, sams-1 RNAi reduces brood size and slightly reproductive timing as well as causes a slender phenotype [16103914]. sams-1 RNAi significantly reduces paralysis in Q35YFP transgenic animals [18331616]. | Worm | +14 to +15 | — | — |
| rsr-1 RNAi | rsr-1 RNAi in the adulthood extends the mean lifespan by 6% without an effect on maximum lifespan [23144747]. | Worm | +6.1 | — | 0 |
| rsp-8 RNAi | rsp-8 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rrt-1 RNAi | rrt-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Kockdown of rrt-1 via RNAi started after the animal reached the late L4 stage increases lifespan by 15-27% [22103665]. | Worm | +15 to +27 | — | — |
| rpt-1 RNAi | rpt-1 RNAi in the adulthood decreases the mean and maximum lifespan by 28 and 50%, respectively [23144747]. | Worm | -28.4 | — | -50.0 |
| rps-9 RNAi | rps-9 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rps-14 RNAi | rps-14 RNAi in the adulthood extends mean and maximum lifespan by 17 and 22% [23144747]. Knockdown of rps-14 via RNAi started after the animal reached the late L4 stage extends lifespan by 6-19% [22103665]. | Worm | +6 to +19 | — | +21.7 |
| rps-12 RNAi | rps-12 RNAi in the adulthood extends mean and maximum lifespan by 12 and 22%, respectively [23144747]. | Worm | +11.6 | — | +21.7 |
| rpn-7 RNAi | rpn-7 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rpn-2 RNAi | rpn-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rpn-11 RNAi | rpn-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25%, respectively [23144747]. | Worm | -19.3 | — | -25.0 |
| rpb-8 RNAi | rpb-8 RNAi in the adulthood extends the mean lifespan by 6% without any apparent effect on maximum lifespan [23144747]. | Worm | +6.4 | — | 0 |
| rpb-3 RNAi | rpb-3 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rpb-2 RNAi | rpb-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rpa-1 RNAi | rpa-1 RNAi in the adulthood extends the mean and maximum lifespan by 5 and 22%, respectively [23144747]. | Worm | +5.1 | — | +21.7 |
| rol-3 RNAi | rol-3 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
GenAge
GenDR
