| RPS27B deletion | Deletion of RPS27B decreases mean replicative lifespan decreased by 20 - 30% in the alpha strain [18423200; 19030232] and by 27% in the ORF collection as well as by 14% in the remade strain [22377630]. | Yeast | -14 to -30 | — | — |
| RPL9B deletion | Deletion of RPL9B increases replicative lifespan by 30% in a strain [18423200; 18340043]. | Yeast | +30 | — | — |
| RPL9A deletion | Deletion of RPL9A increases replicative lifespan by 30% in the alpha strain and 20% in a strain [18423200; 18340043]. | Yeast | +20 to +30 | — | — |
| RPL4A deletion | Deletion of RPL4A increases replicative lifespan by 15% in the alpha strain [18340043]. RPL4A deletion increases replicative lifespan by 20% in the alpha strain [18423200]. | Yeast | +15 to +20 | — | — |
| RPL37B deletion | Deletion of RPL37B increases replicative lifespan by 35% in the alpha strain [18423200]. RPL37B deletion increases replicative lifespan by 35% in the alpha strain and 30% in a strain [19030232]. | Yeast | +30 to +35 | — | — |
| RPL10 deletion | Heterozygosity for RPL10 deletion increases median replicative lifespan by 24% [17174052]. | Yeast | — | +24 | — |
| RAD50 deletion | RAD50 mutations result in a 70% reduced replicative lifespan [10207108]. | Yeast | -70 | — | — |
| PIB1 deletion | Deletion of PIB1 increases replicative lifespan by 25% in the alpha strain [16293764; 19030232]. | Worm | +25 | — | — |
| NMD4 deletion | Deletion of NMD4 increases replicative lifespan [16293764]. NMD4 deletion results in replicative lifespan increase by 25% in the alpha strain and decrease by 20% in a strain [19030232]. | Yeast | -20 to +25 | — | — |
| NDI1 deletion | Deletion of NDI1 results in chronological lifespan extension [16436509]. | Yeast | — | — | — |
| MXR2 deletion | Deletion of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions, but simulatonous deletion of MXR2 together with MXR1 dramatically reduces replicative lifespan by 63% [15141092]. | Yeast | — | — | — |
| MXR1 deletion | Deletion of MXR1 (alias MsrA) decreases (by 25%) the replicative lifespan [15141092]. Deletion of MXR1 decreases replicative lifespan [19049972]. MXR1 deletion decreases replicative lifespan on either glucose or lactate as carbon source [20799725]. Although deletion or overexpression of MXR2 (alias MsrB) has no effect under normal growth conditions, the simultaneous deletion of MXR1 and MXR2 reduces the lifespan by 63% [15141092]. | Yeast | -25 | — | — |
| MRL4 deletion | MRS4 deletion decreases mean replicative lifespan by 30% in the alpha strain and 40% in a strain [18340043; 19030232]. | Yeast | -30 to -40 | — | — |
| MEP3 deletion | Deletion of MEP3 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| MEP2 deletion | Deletion of MEP2 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| MEC1 deletion | MEC1 mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion [17710147]. | Yeast | — | — | — |
| LIN1 deletion | Deletion of LIN1 increases replicative lifespan [16293764]. LIN1 deletion increases replicative lifespan by 40% in the alpha strain [19030232]. | Yeast | +40 | — | — |
| KSS1 deletion | Deletion of KSS1 results in increased sensitivity to heat shock and oxidative stress and a 25% reduction in median chronological lifespan [17662940]. | Yeast | — | -25 | — |
| TEC1 deletion | Absence of TEC1 causes a significant shortened chronological lifespan, but does not block chronological lifespan extension by rapamycin [21840851]. | Yeast | — | — | — |
| SIT4 deletion | SIT4 deletion slightly increases chronological lifespan and totally abolishes the lifespan shortening due to ISC1 deletion [21707788]. | Yeast | — | — | — |
| ISC1 deletion | ISC1 deletion decreases chronological lifespan [21707788; 21707788]. CTA1
overexpression partially suppresses the shortened lifespan by ISC1. Deletion of SIT4 totally rescues the short lifespan of ISC1 mutants [21707788]. HOG1 deletion partially suppresses the premature aging phenotype and short lifespan of ISC1 deletion [22445853]. | Yeast | — | — | — |
| IPT1 deletion | IPT1 deletion decreases mean replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | -30 | — | — |
| INP54 deletion | INP54 deletion increases replicative lifespan by 30% in the alpha strain [19030232]. Deletion of INP54 results in an increase in replicative lifespan by 15% in the alpha strain and a decrease by 15% in the a strain [18340043]. | Yeast | -15 to +30 | — | — |
| INP51 deletion | Deletion of INP51 increases replicative lifespan by 10% in the alpha strain and in a strain [18340043; 19030232]. | Yeast | +10 | — | — |
| INM1 deletion | Deletion of INM1 increases replicative lifespan [16293764]. INM1 deletion results in a replicative lifespan increase by 50% in the alpha strain and a decrease by 10% in a strain [19030232]. | Yeast | -10 to +50 | — | — |
GenAge
GenDR
