Denigma

osm-6 mutation

Species: Nematode (Taxid: 6239)
Factor: osm-6
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Loss-of-function mutation in osm-6 increases lifespan by up to 40% [10617200].

osm-6 mutants are dauer-defective, chemotaxis defective [730048; 8348618], dye-filling defective [9475731], have extremly shortened axonemes, ectopic assembly of ciliary structures and microtubules in many sensory neurons [Perkins et al. 1986]

Mean: +40

References:
  • 10617200: Regulation of lifespan by sensory perception in Caenorhabditis elegans.
  • 9475731: Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans.
  • 8348618: Odorant-selective genes and neurons mediate olfaction in C. elegans.
  • 730048: Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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