Mating type heterozygosity

Species: Budding yeast (Taxid: 4932)
Factor:
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Mating type heterozygosity results in an approximately 20% mean replicative lifespan reduction, which occurs in both haploid and diploid cells (W303R) [10521401] and is likely due to increased homologous recombination [8454201] and rDNA circle formation [10521401].

Mean: -20

References:
  • 10521401: The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
  • 8454201: a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects.




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