Denigma

sir-2.1 overexpression

Species: Nematode (Taxid: 6239)
Factor: sir-2.1
Manipulation: Gain-of-Function, Overexpression
Effect:

sir-2.1 overexpression extends lifespan by about 50% and this lifespan extension depends on DAF-16 activity as it is suppressed by mutation in daf-16 and it does not synergize with daf-2 [11242085].

Overrexpression of sir-2.1 synergizes with TGF-beta mutation (daf-4 and daf-1) for dauer formation [11242085].

Mean: +50

References:
  • 11242085: Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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