Denigma: Intervention

SFA1 YHB1 double mutation

Species: Budding yeast (Taxid: 4932)
Factor: YHB4 SFA1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis during DR-induced replicative lifespan extension is crucial. Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246].

Aging Relevance Analysis/Source:

GenAge