| C14A4.14 | mammalian cell Death Associated Protein related | C14A4.14 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| C16C10.2 | CCDC (human Coiled Coil Domain Containing) homolog | C16C10.2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| C26B2.2 | — | C26B2.2 knockout mutations extend lifespan [15253933]. | Nematode |
| C47D12.2 | TRRAP-like (transcription/transformation domain-associated protein) | C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. | Nematode |
| C47D12.8 | KELch-repeat containing protein | C47D12.8 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| C56C10.10 | related to yeast Vacuolar Protein Sorting factor | C56C10.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| cchl-1 | Cytochrome C Heme-Lyase | cchl-1 RNAi extends mean and maximum lifespan by 55% and 57%, respectively. Lifespan extension by RNAi of cchl-1 is not suppressed by daf-16 [12447374].
cchl-1 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
| cdk-1 | Cyclin-Dependent Kinase family | cdk-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| ceh-6 | Homeobox | ceh-6 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| cha-1 | abnormal CHoline Acetyltransferase 1 | cha-1 encodes a choline acetyltransferase which is expressed in motor [18041778] neurons and downregulated in space. Mutation or RNA interference of cha-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium [22768380]. cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants. RNAi inactivation of cha-1 reduces Q35 aggregation [22768380].
cha-1 participates in determining pharyngeal pumping rate to affect food intake [6698395]. | Nematode |
| che-2 | abnormal CHEmotaxis | che-2 recessive loss-of-function mutations extend lifespan up to 50% (in Bristol N2) [10617200]. che-2 mutants are chemotactic defective, slightly small, defective for osmotic avoidance, have ciliated neurons with abnormal stunted ultrastructure, and are dauer defective [2428682; 1732156]. | Nematode |
| chn-1 | C-term of Hsp70-iNteracting protein (CHIP family) 1 | chn-1 RNAi in the adulthood extends mean and maximum lifespan by 7 and 9%, respectively [23144747]. | Nematode |
| ckr-1 | CholecystoKinin Receptor homolog 1 | ckr-1 RNAi significantly reduces lifespan of eat-2 but not that of age-1 nor clk-1 mutants [19783783]. | Nematode |
| ckr-2 | CholecystoKinin Receptor homolog 2 | ckr-2 RNAi significantly reduces the lifespan of eat-2 but not that of age-1 nor clk-1 mutants [19783783]. | Nematode |
| cnk-1 | Connector/eNhancer of KSR | cnk-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| frh-1 | FRataxin (involved in human Friedrich's ataxia) Homolog | Complete absence of frataxin,the mitochondrial protein defective in individuals with Friedreich ataxia is lethal, while its partial deficiency extends animal lifespan in a p53 dependent manner. Frataxin knockdown via RNAi extends mean and maximum lifespan by 19 and 37%, respectively [23247094].
Substantial reduction of frataxin protein expression is required to extend lifespan, affect sensory neurons functionality, remodel lipid metabolism and trigger autophagy. Beclin and p53 genes are required to induce autophagy and concurrently reduce lipid storages and extend animal lifespan in response to frataxin suppression. Frataxin expression modulates autophagy in the absence of p53 [23247094]. | Nematode |
| csn-5 | COP-9 SigNalosome subunit | csn-5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| ctl-1 | CaTaLase 1 | ctl-1 loss of function shortens lifespan to 77% of wild-type animals. ctl-1 mutants accumulate fluorescent material faster than wild-type, indicating accelerated aging [12610632]. ctl-1 mutation prevents lifespan extension by daf-2 or clk-1. Mutation of ctl-1 reudces catalase activty by 50% [10335847].
All these results have been retracted. | Nematode |
| cup-4 | Coelomocyte UPtake defective 4 | cup-4 RNAi or overexpession reduces oxidative stress resistance and shortens lifespan of wild-type under AL. cup-4 RNAi significantly reduces the extended lifespan of eat-2 mutants, but failed to block lifespan extension of age-1 or clk-1 mutants. Lifespan of cup-4 mutants increases only moderately by sDR [19783783]. | Nematode |
| cup-5 | Coelomocyte UPtake defective 5 | cup-5 RNAi significantly decreases lifespan of eat-2 specifically, whereas lifespan of age-1 or clk-1 mutants are not affected [19783783]. | Nematode |
| cyd-1 | CYclin D | cyd-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| cye-1 | CYclin E | cye-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| cyn-7 | CYclophyliN | cyn-7 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| daf-1 | abnormal DAuer Formation | daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085]. | Nematode |
| daf-14 | abnormal DAuer Formation | daf-14(m77) mutation increases mean lifespan by 21-44% and maximum lifespan by 29% [17900898]. | Nematode |
