| Apo C-I | apolipoprotein C-I | Apo C-I was found to be associated with longevity [9105559]. | Human |
| APOA1 | apolipoprotein A-I | APOA1-MspI-RFLP (-75 nt from the transcription starting site) polymorphism was examined in a healthy population with 304 subjects aged 18-45 years, 267 subjects aged 46-80 years and 229 subjects aged 81-109 years (including 184 subjects, 43 males and 141 females, older than 100 years). The APOA1 allele P, which increases serum LDL-C at middle-age and is over-represented in cardiovascular diseases, tends to increase its frequency in the centenarians males [12556235].APOA1 was found to be associated with longevity [12556235]. | Human |
| APOCIII | apolipoprotein C-III | APOCIII was found to be associated with longevity [8018664]. | Human |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | ARHGEF19 was found to be associated with longevity [22445811]. | Human |
| ART3 | ADP-ribosyltransferase 3 | ART3 was found to be associated with longevity [22445811]. | Human |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | At least one copy of the minor allele of F65 was associated with decreased risk of sporadic dementia of the Alezheimer's type as suggest by a larde epidemiological study [9799084]. Fe65 protein binds to the intracellular domain of the beta-amyloid precursor protein and may modulate the internalization of betaPP. The deletion/substitution of the minor allele occurs with the intron that interrupts the two exons encoding the betaPP binding site. Linkage of the minor allele with resistance to DAT was confirmed in another study in populations over 75 years-of-age [11065130], while epidemiological studies that did not support the linage [11436125; 11099823; 11029529] lacked representation of individuals older than 75 years-old. Any protective effect that the minor allele of Fe65 might have is probably restricted to individuals older than 75 years. | Human |
| ATCAY | ataxia, cerebellar, Cayman type | ATCAY was found to be associated with longevity [21782286]. | Human |
| ATK1 | v-akt murine thymoma viral oncogene homolog 1 | ATK1 was found to be associated with longevity [21418511]. | Human |
| Atp5j2 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 | Atp5j2 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| ATP8 | — | ATP8 was found to be associated with longevity [10996007]. | Human |
| ATP8_RAT | ATP synthase protein 8 | ATP8_RAT is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| ATP9B | ATPase, class II, type 9B | ATP9B was found to be associated with longevity [21782286]. | Human |
| B9D2 + TGFB1 | — | B9D2 + TGFB1 was found to be associated with longevity [15569360]. | Human |
| BAT5 | abhydrolase domain containing 16A | BAT5 was found to be associated with longevity [22279548]. | Human |
| Bbs1 | Bardet-Biedl syndrome 1 protein | Bbs1 is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | BDH1 was found to be associated with longevity [22445811]. | Human |
| F7 | coagulation factor VII (serum prothrombin conversion accelerator) | Blood coagulation factor VII (FVII) R/Q353 and FVII-323ins10 SNPs were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years). R/Q353 and FVII-323ins10 manifest significant influences on survival in males, with reduced hazards of death for carriers of the Q353 allele and the FVII-323P10 allele [11602206].F7 was found to be associated with longevity [15621215]. F7 was found to be associated with longevity [10744171]. F7 was found to be associated with longevity [10744171]. F7 was found to be associated with longevity [11602206]. | Human |
| BRCA1 | breast cancer 1, early onset | BRCA1 was found to be associated with longevity [11795532]. BRCA1 was found to be associated with longevity [11795532]. | Human |
| BRE | brain and reproductive organ-expressed (TNFRSF1A modulator) | BRE was found to be associated with longevity [22279548]. | Human |
| BTBD9 | BTB (POZ) domain containing 9 | BTBD9 was found to be associated with longevity [22533364]. | Human |
| BTG3 | BTG family, member 3 | BTG3 was found to be associated with longevity [22279548]. | Human |
| BTNL2 | butyrophilin-like 2 (MHC class II associated) | BTNL2 was found to be associated with longevity [22279548]. | Human |
| BUD31 | BUD31 homolog (S. cerevisiae) | BUD31 was found to be associated with longevity [21418511]. | Human |
| C2 | complement component 2 | C2 was found to be associated with longevity [22279548]. C2 was found to be associated with longevity [24244950]. | Human |
| C20orf79 | chromosome 20 open reading frame 79 | C20orf79 was found to be associated with longevity [22279548]. | Human |
