Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

prometheus--2.jpg

  • symbol name observation species
    ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ABCC4 was found to be associated with longevity [22533364]. Human
    ABL1 c-abl oncogene 1, non-receptor tyrosine kinase ABL1 was found to be associated with longevity [22445811]. Human
    AC000050.2 AC000050.2 was found to be associated with longevity [22533364]. Human
    ACCN1 amiloride-sensitive cation channel 1, neuronal ACCN1 was found to be associated with longevity [22279548]. Human
    ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ACE was found to be associated with longevity [12954489]. Human
    ACE1 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ACE1 was found to be associated with longevity [12954489]. Human
    ACPL2 acid phosphatase-like 2 ACPL2 was found to be associated with longevity [22445811]. Human
    ADA adenosine deaminase ADA was found to be associated with longevity [20174870]. ADA was found to be associated with longevity [21865054]. Human
    ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 ADAMTS6 was found to be associated with longevity [22445811]. Human
    ADARB1 adenosine deaminase, RNA-specific, B1 ADARB1 was found to be associated with longevity [20011587]. Human
    ADARB2 adenosine deaminase, RNA-specific, B2 ADARB2 was found to be associated with longevity [20011587]. ADARB2 was not found to be associated with longevity [20011587]. Human
    ADCY2 adenylate cyclase 2 (brain) ADCY2 was found to be associated with longevity [19641380]. Human
    ADCY6 adenylate cyclase 6 ADCY6 was found to be associated with longevity [23020224]. Human
    Adcy8 Adenylate cyclase type 8 Adcy8 is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. Norway rat
    ADIPOQ10 adiponectin, C1Q and collagen domain containing ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [23339001]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was not found to be associated with longevity [18765803]. Human
    ADIPQO adiponectin, C1Q and collagen domain containing ADIPQO was not found to be associated with longevity [20201642]. ADIPQO was found to be associated with longevity [20201642]. Human
    ADRB2 adrenergic, beta-2-, receptor, surface ADRB2 was found to be associated with longevity [23020224]. ADRB2 was not found to be associated with longevity [23020224]. Human
    AGTR1 angiotensin II receptor, type 1 AGTR1 was found to be associated with longevity [22569962]. AGTR1 was not found to be associated with longevity [22569962]. Human
    AIF1 allograft inflammatory factor 1 AIF1 was found to be associated with longevity [22279548]. Human
    AKT1 v-akt murine thymoma viral oncogene homolog 1 AKT1 was found to be associated with longevity [19489743]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was not found to be associated with longevity [22929028]. Human
    ALDH2 (for males) aldehyde dehydrogenase 2 family (mitochondrial) ALDH2 (for males) was found to be associated with longevity [19641380]. Human
    MT-RNR2 An single nucleotide polymorphism in MT-RNR2 is associated with longevity [18759861]. Human
    ANGEL1 angel homolog 1 (Drosophila) ANGEL1 was found to be associated with longevity [22279548]. Human
    ANK2 ankyrin 2, neuronal ANK2 was found to be associated with longevity [22445811]. Human
    APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 APBB2 was found to be associated with longevity [22279548]. Human
    Factors are an extension of GenAge and GenDR.

    Comment on This Data Unit