| tkt-1 | — | RNA interference of tkt-1 increases mean lifespan by 25% [17608836]. | Nematode |
| IRC14 | — | Deletion of IRC14 increases mean replicative lifespan by 14-22% [16293764].
IRC14 is a dubious ORF overlapping IDH2. | Budding yeast |
| YDR248C | — | Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| YDR307W | — | Deletion of YDR307W increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YER186C | — | Deletion of YER186C increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YER187W | — | Deletion of YER187W increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YGL235W | — | YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| YLR422W | — | Deletion of YLR422W increases replicative lifespan by 25% in the alpha strain [19030232]. | Budding yeast |
| YMR010W | — | Deletion of YMR010W increases replicative lifespan by 30% in the alpha strain [18340043]. | Budding yeast |
| SCH9 | — | Transposon-mediated mutagenesis of SCH9, which encodes for a serine threonine kinase homologous to Akt/PKB, increases resistance to oxidants and thermal stress as well as extends chronological lifespan by 30%. SCH9 deletion increases chronological lifespan by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this life-extension. Deletion of the mitochondrial antioxidant enzyme superoxide dismutase gene SOD2 prevents the increased chronological lifespan caused by SCH9 deletion [11292860]. Mutations that decrease the activity of the Ras/Cyr1/PKA pathway also extend longevity and increase stress resistance by activating transcription factors Msn2/Msn4 and Sod2 [12855292]. SCH9 deletion mutants exhibit more than 3-fold extension of chronological lifespan. By day 9 of medium depletion all the wild-type cells were dead while 50% sch9 mutants survived [17710147]. Deletion of SCH9 also increases resistance to heat shock and oxidative stress [11292860], and increases replicative lifespan by 18% (in DBY746) [12586694]. SCH9 deletion increases the replicative lifespan by 40% in the alpha strain [18340043] and increases mean chronological lifespan by 97 - 246% (97, 133, 154, 226, 246) in diploid cells [21447998]. Mutation or deletion of SCH9 increases resistance to oxidants and extends chronological lifespan [11292860; 16286010]. The extended lifespan of SCH9 deletion mutants is not further extended by low glucose DR and is independent of Sir2 [16293764]. Deletion of RIM15 or GIS1 reverses chronological lifespan extension associated with sch9Delta. Water restriction further increases chronological lifespan of sch9Delta [18225956]. Deletion of SCH9 results in a longer chronological lifespan [21076178]. | Budding yeast |
| MEP2 | — | Deletion of MEP2 extends chronological lifespan [16418483]. | Budding yeast |
| MEP3 | — | Deletion of MEP3 extends chronological lifespan [16418483]. | Budding yeast |
| RPS6B | — | RPS6B deletion increases mean replicative lifespan by about 30% [16293764]. Deletion of RPS6B, but not of the RPS6A paralog increases replicative median lifespan robustly by 45% [17174052]. | Budding yeast |
| YSC84 | — | Deletion of YSC84 increases replicative lifespan by 20% in the alpha strain [19030232]. YSC84 deletion increases replicative lifespan by 25% in the alpha strain [18340043]. | Budding yeast |
| age-2 | — | Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. | Nematode |
| B0491.5 | — | RNA interference of B0491.5 in adulthood results in a 16% increase in mean lifespan [17521386]. | Nematode |
| B0546.3 | — | RNA interference of B0546.3 increases mean lifespan by 27% [17608836]. | Nematode |
| C18E9.10 | — | RNA interference of C18E9.10 results in lifespan extension [15998808]. | Nematode |
| C26B2.2 | — | C26B2.2 knockout mutations extend lifespan [15253933]. | Nematode |
| C27B7.7 | — | RNA interference of C27B7.7 extends lifespan [15998808]. | Nematode |
| C32H11.1 | — | RNA interference of C32H11.1 extends lifespan [12845331]. | Nematode |
| C32H11.5 | — | RNA interference of C32H11.5 extends lifespan [15998808]. | Nematode |
| C33A12.1 | — | RNA interference of C33A12.1 increase mean lifespan by 40% [17608836]. | Nematode |
| C33F10.12 | — | RNA interference of C33H5.18 extends lifespan [15998808]. | Nematode |
| C35A11.3 | — | RNA interference of C35A11.3 extends lifespan [15998808]. | Nematode |
