Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    ND2 ND2 was not found to be associated with longevity [12384792]. Human
    MT-ND3 MT-ND3 was not found to be associated with longevity [18759861]. Human
    APOE + TOMM40 APOE + TOMM40 was not found to be associated with longevity [21418511]. APOE + TOMM40 was not found to be associated with longevity [23040522]. Human
    ND2 ND2 was not found to be associated with longevity [12384792]. Human
    Downstream of LACE1 Downstream of LACE1 was not found to be associated with longevity [19196970]. Human
    Downstream of FOXO3A Downstream of FOXO3A was found to be associated with longevity [19196970]. Downstream of FOXO3A was not found to be associated with longevity [19196970]. Human
    IL6 + APOE IL6 + APOE was not found to be associated with longevity [15236771]. Human
    PTK2 PTK2 was found to be associated with longevity [24930376]. PTK2 was not found to be associated with longevity [24930376]. Human
    PVRL2 PVRL2 was found to be associated with longevity [24924924]. PVRL2 was not found to be associated with longevity [24924924]. Human
    SOD3 SOD3 was not found to be associated with longevity [24163049]. Human
    ATF4 ATF4 was not found to be associated with longevity [23770741]. Human
    CBL CBL was not found to be associated with longevity [23770741]. Human
    JUN JUN was not found to be associated with longevity [23770741]. Human
    NOS1 NOS1 was not found to be associated with longevity [23572278]. Human
    NOS3 NOS3 was not found to be associated with longevity [23572278]. Human
    TP53 tumor protein p53 A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215]. Human
    PDPK1 3-phosphoinositide dependent protein kinase-1 PDPK1 was not found to be associated with longevity [19489743]. Human
    ACTN3 actinin, alpha 3 ACTN3 was not found to be associated with longevity [21407828]. Human
    ADARB2 adenosine deaminase, RNA-specific, B2 ADARB2 was found to be associated with longevity [20011587]. ADARB2 was not found to be associated with longevity [20011587]. Human
    ADCY5 adenylate cyclase 5 ADCY5 was not found to be associated with longevity [23020224]. Human
    ADIPQO adiponectin, C1Q and collagen domain containing ADIPQO was not found to be associated with longevity [20201642]. ADIPQO was found to be associated with longevity [20201642]. Human
    ADIPOQ10 adiponectin, C1Q and collagen domain containing ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [23339001]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was not found to be associated with longevity [18765803]. Human
    ADRB1 adrenergic, beta-1-, receptor ADRB1 was not found to be associated with longevity [23020224]. Human
    ADRB2 adrenergic, beta-2-, receptor, surface ADRB2 was found to be associated with longevity [23020224]. ADRB2 was not found to be associated with longevity [23020224]. Human
    ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ACE was not found to be associated with longevity [12634288]. Human
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    • 25 of 196 factors
    Factors are an extension of GenAge and GenDR.

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