PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study.

Authors: Garatachea N; Fuku N; He ZH; Tian Y; Arai Y; Abe Y; Murakami H; Miyachi M; Yvert T; Venturini L; Santiago C; Santos-Lozano A; Rodriguez-Romo G; Ricevuti G; Pareja-Galiano H; Sanchis-Gomar F; Emanuele E; Hirose N; Lucia A

Abstract: Focal adhesion is critical for cell survival. The 'focal adhesion kinase' (FAK, or PTK2) is an important component of the human 'interactome' and thus a potential 'longevity-related protein'. Here we studied the association between two PTK2 gene SNPs (rs7843014, rs7460) and exceptional longevity (EL). Besides gaining insight into their functionality (by determining luciferase gene reporter activity), we studied the genotype/allele frequency of these two SNPs among three different cohorts: (i) Spanish centenarians (n=175, 100-111y, 144 women) and healthy controls (n=355, 20-50y, 284 women); (ii) Italian centenarians (n=79, 100-104y, 40 women) and controls (n=316, 29-50y, 156 women); and (iii) Japanese centenarians (n=742, 100-116y, 623 women) and healthy controls (n=499, 23-59y, 356 women). Both SNPs had functional significance, with the A-allele up-regulating luciferase activity compared to the other allele (rs7460 T-allele and rs7843014 C-allele, respectively). The A-allele of both SNPs was negatively associated with EL in the Spanish cohort [rs7460: odds ratio (OR) adjusted by sex=0.40 (95% confidence intervals (CI): 0.3, 0.6, P<0.001); rs7843014: OR=0.37 (95%CI: 0.3, 0.5), P<0.001]. The OR of being a centenarian if having the rs7460-TT genotype was 6.68 (95%CI: 4.1, 10.8, P<0.001). The rs7843014 CC genotype was also positively associated with EL [OR=7.58 (95%CI: 4.6, 12.3), P<0.001]. No association was however found for Italians or Japanese. Thus, two genotypes of the FAK gene, rs7460 TT and rs7843014 CC are possibly associated with lower gene expression, and might favor the likelihood of reaching EL in the Spanish population. Further research is needed to unveil the mechanisms by which FAK expression could maybe influence rate of aging.

Journal: Rejuvenation research
Date: June 17, 2014
PMID: 24930376
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Garatachea N, Fuku N, He ZH, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Venturini L, Santiago C, Santos-Lozano A, Rodriguez-Romo G, Ricevuti G, Pareja-Galiano H, Sanchis-Gomar F, Emanuele E, Hirose N, Lucia A (2014) PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. Rejuvenation research.

Longevity Variant Associations (p-value):
  • rs7843014 (0.001)
  • rs7460 (0.001)
  • rs7843014 (1.0)
  • rs7460 (1.0)
  • rs7843014 (1.0)
  • rs7460 (1.0)

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